纳入病例检测的COVID-19数学模型的稳定性和分岔分析

O. Odetunde, M. Ibrahim, O. T. Olotu, O. Uwaheren, S. T. Akinyemi
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引用次数: 0

摘要

2019年12月,新冠肺炎在中国武汉首次被发现,并于2020年成为全球家喻户晓的名字。这是一场全球性的流行病,由于大规模死亡的威胁,它迫使人类强制性放假,在2020年的大部分时间里,所有国家的经济都关闭了。这一大流行病的威胁是用人类的全部能力来对付的。其中一种武器是发现病例,导致自我隔离或隔离。这一武器有助于减少人群中未被发现的无症状/有症状携带者可能引起的新病例数量。本文通过建立一个数学模型,结合病例发现、致敏影响和早期诊断在遏制该疾病传播中的作用,研究了COVID-19的传播动态。讨论了该模型解的存在性、唯一性和有界性等基本性质。此外,发现该模型表现出两种平衡状态,即无病(DFE)和大流行平衡状态。计算了模型的繁殖数,并用于建立两种平衡状态的稳定性分析。采用中心流形理论对模型进行分岔分析,结果表明,当再生数大于等于1时,模型出现正向分岔。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
STABILITY AND BIFURCATION ANALYSIS OF COVID-19 MATHEMATICAL MODEL INCORPORATING CASE DETECTION
COVID-19 became a household name globally in the year 2020 after it was first discovered in Wuhan, China in December 2019. It is a global pandemic that shut the economy of all nations in the larger part of year 2020 by forcing a compulsory holiday on mankind due to its threat of mass death. The menace of this pandemic was combated with the total arsenal in human capacity. One of such weapons is case detection that leads to either self-isolation or quarantine. This weapon helps to reduce the number of new cases that may arise from undetected asymptomatic/symptomatic carriers within a population. In this article, the dynamics of COVID-19 transmission were studied by developing a mathematical model incorporating case detection, the impact of sensitization, and role of early diagnosis in curbing the spread of this disease. The basic properties in terms of existence, uniqueness, and boundedness of solution for the formulated model were discussed. Also, the model was found to exhibit two equilibrium states which are categorised as the disease-free (DFE) and pandemic equilibrium states. The reproductive number for the model was computed and used to establish the stability analysis for both equilibrium states. Center manifold theory was employed to assess the bifurcation analysis of the model and the result shows that the model exhibits forward bifurcation when the reproductive number is greater than and equal to 1.
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