葱(Allium Ascalonicum L.)配方研究乙醇提取物凝胶治疗大鼠切除创面

Fahmi Sidiq, Kamaludin Kamaludin, R. H. Kankarofi
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引用次数: 0

摘要

洋葱鳞茎(Allium ascalonicum L.)含有生物碱化合物和皂苷,可以加速伤口愈合过程。因此,我们研究了以凝胶形式切除洋葱(Allium ascalonicum L.)乙醇提取物对小鼠(Rattus novergicus)的伤口愈合作用。本研究旨在研究大葱醇提物凝胶剂型的稳定性、对切除创面愈合的效果及最佳浓度。使用的浓度变量为5%、10%和20%。使用的方法是通过浸渍提取样品,创面凝胶以3种浓度制作,即5%、10%和20%,然后通过4⁰C和40⁰C循环测试方法对制备进行稳定性测试,进行6个循环。在此基础上,以凝胶基为阴性对照,以octadine®凝胶为阳性对照,用手术刀损伤大鼠背部皮肤。伤口凝胶制备稳定性的观察结果在4⁰C和40⁰C下都是稳定的。从治疗开始就减少创面长度,直至创面完全闭合,结果表明,以20%浓度的葱茎乙醇提取物凝胶制剂能减少和愈合大鼠创面,创面愈合效果最好。洋葱鳞茎(Allium ascalonicum L.)含有生物碱化合物和皂苷,可以加速伤口愈合过程。因此,我们研究了以凝胶形式切除洋葱(Allium ascalonicum L.)乙醇提取物对小鼠(Rattus novergicus)的伤口愈合作用。本研究旨在研究大葱醇提物凝胶剂型的稳定性、对切除创面愈合的效果及最佳浓度。使用的浓度变量为5%、10%和20%。使用的方法是通过浸渍提取样品,创面凝胶以3种浓度制作,即5%、10%和20%,然后通过4⁰C和40⁰C循环测试方法对制备进行稳定性测试,进行6个循环。在此基础上,以凝胶基为阴性对照,以octadine®凝胶为阳性对照,用手术刀损伤大鼠背部皮肤。伤口凝胶制备稳定性的观察结果在4⁰C和40⁰C下都是稳定的。从治疗开始就减少创面长度,直至创面完全闭合,结果表明,以20%浓度的葱茎乙醇提取物凝胶制剂能减少和愈合大鼠创面,创面愈合效果最好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Studying the Formulation of Shallot (Allium Ascalonicum L.) Ethanol Extract Gel as Treatment of Excision Wounds in Rats
Onion bulbs (Allium ascalonicum L.) contain alkaloid compounds and saponins which can accelerate the wound healing process. Therefore, a study was conducted on the wound healing effect of excision of ethanol extract of onion bulbs (Allium ascalonicum L.) in the form of a gel against mice (Rattus novergicus). The purpose of this research was to study the stability of the preparation as well as the effectiveness and optimum concentration in excision wound healing from the ethanolic extract of shallot (Allium ascalonicum L.) in gel dosage form. The concentration variants used were 5%, 10%, and 20%. The method used was sample extraction by maceration and wound gel was made in 3 concentrations, namely 5%, 10%, and 20% then a stability test was carried out on the preparation by cycling test method at 4⁰C and 40⁰C for 6 cycles. Besides that, gel base was also used as a negative control and octadine® gel as a positive control, then the back skin of a rat (Rattus novergicus) was injured using a surgical knife. The results of the observation of the stability of the wound gel preparation were stable both at 4⁰C and at 40⁰C. Reduction of the length of the wound at the beginning of the treatment until the wound was completely closed showed that the ethanol extract gel preparation of shallot bulbs (Allium ascalonicum L.) could reduce and heal cuts in rats with a concentration of 20% which showed the most effective wound healing effect.Onion bulbs (Allium ascalonicum L.) contain alkaloid compounds and saponins which can accelerate the wound healing process. Therefore, a study was conducted on the wound healing effect of excision of ethanol extract of onion bulbs (Allium ascalonicum L.) in the form of a gel against mice (Rattus novergicus). The purpose of this research was to study the stability of the preparation as well as the effectiveness and optimum concentration in excision wound healing from the ethanolic extract of shallot (Allium ascalonicum L.) in gel dosage form. The concentration variants used were 5%, 10%, and 20%. The method used was sample extraction by maceration and wound gel was made in 3 concentrations, namely 5%, 10%, and 20% then a stability test was carried out on the preparation by cycling test method at 4⁰C and 40⁰C for 6 cycles. Besides that, gel base was also used as a negative control and octadine® gel as a positive control, then the back skin of a rat (Rattus novergicus) was injured using a surgical knife. The results of the observation of the stability of the wound gel preparation were stable both at 4⁰C and at 40⁰C. Reduction of the length of the wound at the beginning of the treatment until the wound was completely closed showed that the ethanol extract gel preparation of shallot bulbs (Allium ascalonicum L.) could reduce and heal cuts in rats with a concentration of 20% which showed the most effective wound healing effect.
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