使用多通道、生物相容性有机电化学晶体管记录大脑活动

Mengge Wu, K. Yao, Junsheng Yu, Xinge Yu
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引用次数: 0

摘要

大脑活动的活体记录对于诊断目的和脑科学研究至关重要。有机电化学晶体管(OECTs)由于其优良的信噪比、机械灵活性和生物相容性而成为最有前途的候选材料之一。在这里,我们提出了一种多通道、生物相容性的OECT阵列的工程设计,它能够无缝地贴合到软组织上,以高时空分辨率监测神经元放电。该装置在活体大鼠模型上的成功演示,证明了该技术在临床应用、人机界面、超空间等方面的巨大潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recording of brain activity using multichannel, biocompatible organic electrochemical transistors in vivo
In vivo recordings of brain activity are vital for diagnostic purposes and brain science research. Organic electrochemical transistors (OECTs) are one of the most promising candidates due to their excellent signal-to-noise ratio, mechanical flexibility, and biocompatibility. Here, we propose the engineering of a multichannel, biocompatible OECT array, that is capable of laminating onto soft tissues seamlessly, monitoring neuron firing with high spatiotemporal resolution. The successful demonstrations of this device to map micro-electrocorticography in the rat model in vivo, demonstrate the great potential of this technology for clinical applications, human-brain interfaces, metaverse, etc.
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