改进的药物输送:喷雾冷冻干燥纳米脂质体吸入气溶胶

2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04) Pub Date : 2004-08-25 DOI:10.1109/ICMENS.2004.80

Zhao-quan Wang, R. Löbenberg, L. Sweeney, J. Wong, W. Finlay

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引用次数: 1

摘要

采用喷雾冷冻干燥的方法制备了一种用于雾化吸入给药的纳米脂质体粉末制剂。经盐水重构后，91%的脂质体颗粒(平均体积大小)小于600 nm。在气溶胶分散后，使用一种新的被动吸入器(专利申请中)，以60 l/min的吸入流速，使用模型药物(环丙沙星)，该配方的细颗粒分数(FPF)超过80%。

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Improved Drug Delivery: Spray Freeze Dried Nano-Liposomal Inhaled Aerosols

A novel powder formulation for inhaled aerosol drug delivery of nano-liposomes has been prepared using spray-freeze drying. After saline reconstitution 91% of the liposome particles (mean volume size) were found to be smaller than 600 nm. Upon aerosol dispersion, a fine particle fraction (FPF) of more than 80% was achieved for this formulation with a model drug (ciprofloxacin) using a new passive inhaler (patent pending) at an inhalation flow rate of 60 l/min.

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来源期刊

2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)

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