Rash in an Extremely Low Birth Weight Infant

Primary cutaneous aspergillosis (PCA) is one of several invasive fungal infections that have increased in incidence in the last four decades. We present a case of an extremely low birth weight infant born at 24 weeks gestation diagnosed with cutaneous aspergillosis, highlighting the risk factors and clinical findings associated with neonatal PCA. Additionally, we discuss use of serum galactomannan testing as well as combination amphotericin B and voriconazole therapy. Early recognition of lesions characteristic of PCA is required to ensure prompt diagnosis and treatment, potentially preventing dissemination with favorable outcomes.