d -二聚体水平预测COVID-19 ICU患者住院死亡率

R. Hasani, Mohan N. Nerkar, P. Rahate, Venus Sadhwani
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摘要

冠状病毒病2019 (COVID-19)是由严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)引起的一种新发现的传染病,导致重症监护病房(ICU)的各种入院和死亡。常见的实验室值可能为COVID-19患者提供关键信息,并可能预测发病率和预后。本研究的目的是评估d -二聚体水平升高与COVID-19住院ICU患者死亡率的关系。回顾性纳入2020年7月27日至2020年10月30日在那格浦尔七星医院的所有实验室确诊的COVID-19 ICU患者。收集所有ICU患者入院时、第3天和第5天的d -二聚体水平,并收集死亡事件。将受试者分为出院组和过期组。然后比较两组间d -二聚体水平,评估d -二聚体水平与医院死亡率的预测价值。共有101名符合条件的患者参加了这项研究。31人在住院期间死亡。死亡患者入院时d -二聚体水平为2729±3243 ng/mL,出院时d -二聚体水平为973±1553 ng/mL (P < 0.007)。死亡患者第3天d -二聚体为3206.5±3338.8,出院患者为828.8±1268.8 (P = 0.001)。死亡患者第5天d -二聚体为5184。5±3386.1 vs出院患者为588.7±645.5 (P < 0.0001)。死亡患者住院天数14.22±6.7天,存活患者住院天数7.6±5.9天。我们认为,从入院到第5天,d -二聚体呈增加趋势的SARS-CoV-2感染患者的临床结局(全因死亡率)较差,因此入院时d -二聚体的测定及其趋势可以指导临床决策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
D-dimer Levels to Predict in-Hospital Mortality in ICU Patients with COVID-19
Coronavirus disease 2019 (COVID-19) is a recently described infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing various intensive care unit (ICU) admissions and deaths. Common laboratory values may provide key insights into patients with COVID-19, and may predict the morbidity and outcome. The aim of this study was to evaluate the relation of elevated D-dimer levels on mortality of patients admitted to ICU with COVID-19. All ICU patients with laboratory confirmed COVID-19 were retrospectively enrolled in Sevenstar Hospital, Nagpur from 27 July, 2020, to 30 October, 2020. D-dimer levels on admission, on Day 3 and Day 5, were collected in all ICU patients and death events were collected. The subjects were divided into two groups discharged and expired. Then, the D-dimer levels between two groups were compared to assess the predictive value of D-dimer level and mortality in hospitals. A total of 101 eligible patients were enrolled in the study. Thirty-one deaths occurred during hospitalisation. Patients who expired had on admission D-dimer levels of 2729 ± 3243 ng/mL while those discharged had D-dimer values of 973 ± 1553 ng/mL (P < 0.007). D-dimer of expired patients on Day 3 was 3206.5 ± 3338.8 and of discharged patients was 828.8 ± 1268.8 (P = 0.001). D-dimer of expired patients on Day 5 was 5184. 5 ± 3386.1 versus discharged patients was 588.7 ± 645.5 (P < 0.0001). Number of Days in ICU for patients who expired was 14.22 ± 6.7 while for those who survived 7.6 ± 5.9. We conclude that SARS-CoV-2 infected patients with increasing trend of D-dimer (from admission to day 5) have worse clinical outcomes (all-cause mortality), and thus, measurement of D-dimers on admission and its trend can guide clinical decision-making.
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