Trends and profile of SARS-CoV-2 infection following COVID vaccination among health-care workers

Introduction: Health-care workers (HCWs) across the country were administered Covishield (COVID vaccination) in a phased manner. This study aimed to explore the trends in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection postvaccination among HCWs, with a view of the demographic and clinical features among a subset of those affected. Materials and Methods: A cross-sectional study was performed at a tertiary care center among HCWs who were affected following vaccination during the period April 2021–October 2022. A Google Form was sent out to assess the disease profile and transmission dynamics of which a subset was returned. Results: A total of 1657 HCWs tested positive for coronavirus disease-2019 (COVID-19) during the period April 2021–October 2022. Of these, 77.42% were females and 92.67% were completely vaccinated. Nurses were the majority (46.30%) and the least-doctors (6.63%). The most common symptom presentation was cough (76.90%) and fever (73.50%), whereas anosmia, ageusia, and breathing difficulty were minimal. The mean duration between second dose and turning positive was between 165.54 ± 121.98 days. Among HCWs who turned positive, only 7.10% required hospital admission and only one person needed intensive care unit admission. Among those who reported positive, 54.60% mentioned that their close contacts subsequently turned positive. Of these, workplace and household contacts were 49.2% and 46.2%, respectively. Conclusion: The predominant symptoms in COVID-19 infection postvaccination are fever, cough, and myalgia. However, the severity of the infection was decreased, requiring mostly home isolation. Transmission of infection was mainly to household and workplace close contacts.