线性延迟反馈控制抑制帕金森病群体模型中的β振荡

Jingyu Yang, Y. Che
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引用次数: 0

摘要

帕金森病(PD)是第二常见的退行性神经系统疾病。当患者患有PD时,脑电图(EEG)会产生β振荡。脑深部电刺激(DBS)是治疗帕金森病最成功的方法之一,但DBS控制方案仍有待改进。在本文中,我们在神经计算群体模型中测试了针对丘脑下核(STN)或内部苍白球(GPi)的DBS线性延迟反馈控制,描述了皮层丘脑皮质基底节网络的动态。数值模拟结果表明,STNDBS和GPI-DBS都能有效地控制PD状态的β振荡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Beta Oscillations Suppression in a Population Model of Parkinson’s Disease by Linear Delayed Feedback Control
Parkinson’s disease (PD) is the second most prevalent degenerative neurological illness. Beta oscillations in electroencephalogram (EEG) are produced when a patient is suffering from PD. Deep brain stimulation (DBS) is one of the most successful treatments for PD, however, DBS control schemes still need improvement. In this paper, we test linear delay feedback control for DBS targeted the subthalamic nucleus (STN) or the internal globus pallidus (GPi) in a neural computing population model, describing dynamics of the cortex thalamocortical basal ganglia network. The numerical simulations show that both STNDBS and GPI-DBS can efficiently control beta oscillations of the PD state in term of frequency decrease.
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