结核分枝杆菌感染并发矽肺

Patricia Petculescu, Andrei S. Nastase, Ana-Maria Mănescu, M. Oțelea
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引用次数: 0

摘要

罗马尼亚是欧洲公认的结核病发病率最高的国家。肺结核与矽肺的关联决定了肺泡巨噬细胞的协同免疫抑制,导致更高程度的肺实质破坏,从而导致呼吸衰竭。病例报告接近患者矽肺和相关的活动性继发性肺结核的第三期阳性涂片。已知结核分枝杆菌(MTB)感染激活的影响是严重的,使矽肺的预后恶化并降低患者的生活质量。鉴于肺结核的高发病率,矽肺患者的肺结核早期诊断是至关重要的,有时不能通过常规的细菌学检查来实现。因此,在硅结核中应考虑一种更好的策略,即通过检测IFN-γ诱导蛋白10生物标志物等最新检测的阳性预测值来预防潜伏结核灶的进展,这可能有助于早期发现和治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Complicated Silicosis Associated with Mycobacterium tuberculosis Infection
Abstract Romania is recognized as the European country with the highest tuberculosis rate in Europe. The association of tuberculosis with silicosis determines synergistic immunosuppression of the alveolar macrophages resulting in a higher grade of pulmonary parenchymal destruction and consequently respiratory failure. The case report approaches a patient with third stage of silicosis and associated active secondary pulmonary tuberculosis disease with positive smears. The impact of the Mycobacterium tuberculosis (MTB) infection’s activation is known to be severe, worsening the prognosis of silicosis and reducing the patient’s quality of life. Regarding the high morbidity rate of tuberculosis, an early diagnosis of tuberculosis in patients with silicosis is paramount, and sometimes cannot be achieved by usual bacteriological tests. Therefore, a better strategy is to be considered in silicotuberculosis, namely to prevent the progression of the latent tuberculosis foci by testing the positive predictive value of up-to-date tests such as IFN-γ inducible protein 10 biomarker, which may allow early detection and treatment.
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