抗血小板治疗在心血管疾病预防中的新途径

K.M. Shamilyan
{"title":"抗血小板治疗在心血管疾病预防中的新途径","authors":"K.M. Shamilyan","doi":"10.56936/18290825-2022.16.3-91","DOIUrl":null,"url":null,"abstract":"Cardiovascular diseases are considered to be the leading cause of mortality in the world.Modifiable and non modifiable risk factors with different mechanisms affect the endothelial cells and lead to development of endothelial dysfunction. Endothelial dysfunction as a cornerstone of cardiovascular diseases’ pathophysiological mechanisms, causes overactivation and over aggregation of platelets resulting in the development of ischemic complications.Though we have huge arsenal of antiplatelet and anticoagulant drugs used for prevention and treatment of ischemic consequences, there is an increase of annual cases of side effects associated with pharmacotherapy.The “gold standard” of antiplatelet therapy - Aspirin gradually loses its role and importance in the primary and secondary prevention, as well as at the treatment of cardiovascular diseases due to the haemorrhage mostly on those patients who are under 70, have diabetes or are in the low and mild risk group of cardiovascular disease.That is why the development of newer and safer substances with possible less hemorrhagic complications has become an important task of modern medicine.In this point of view the plant based agents, containing rich composition of polyphenolic substances, particularly anthocyanins and flavonoids, could serve as potent and promising sources due to their antiplatelet effects, which is conditioned with several action mechanisms.Each action mechanism of polyphenolic substances is directed to the different phases of platelet aggregation. In this paper we have discussed the mechanisms and side effects of antiplatelet drugs with proven activity, the plants as a source for developing new and safe antiplatelet dosage forms and the technological ways to develop optimal drug dosage forms.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"56 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New approaches of antiplatelet therapy in the prevention of cardiovascular diseases\",\"authors\":\"K.M. Shamilyan\",\"doi\":\"10.56936/18290825-2022.16.3-91\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cardiovascular diseases are considered to be the leading cause of mortality in the world.Modifiable and non modifiable risk factors with different mechanisms affect the endothelial cells and lead to development of endothelial dysfunction. Endothelial dysfunction as a cornerstone of cardiovascular diseases’ pathophysiological mechanisms, causes overactivation and over aggregation of platelets resulting in the development of ischemic complications.Though we have huge arsenal of antiplatelet and anticoagulant drugs used for prevention and treatment of ischemic consequences, there is an increase of annual cases of side effects associated with pharmacotherapy.The “gold standard” of antiplatelet therapy - Aspirin gradually loses its role and importance in the primary and secondary prevention, as well as at the treatment of cardiovascular diseases due to the haemorrhage mostly on those patients who are under 70, have diabetes or are in the low and mild risk group of cardiovascular disease.That is why the development of newer and safer substances with possible less hemorrhagic complications has become an important task of modern medicine.In this point of view the plant based agents, containing rich composition of polyphenolic substances, particularly anthocyanins and flavonoids, could serve as potent and promising sources due to their antiplatelet effects, which is conditioned with several action mechanisms.Each action mechanism of polyphenolic substances is directed to the different phases of platelet aggregation. In this paper we have discussed the mechanisms and side effects of antiplatelet drugs with proven activity, the plants as a source for developing new and safe antiplatelet dosage forms and the technological ways to develop optimal drug dosage forms.\",\"PeriodicalId\":353660,\"journal\":{\"name\":\"THE NEW ARMENIAN MEDICAL JOURNAL\",\"volume\":\"56 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"THE NEW ARMENIAN MEDICAL JOURNAL\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.56936/18290825-2022.16.3-91\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"THE NEW ARMENIAN MEDICAL JOURNAL","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.56936/18290825-2022.16.3-91","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

心血管疾病被认为是世界上死亡的主要原因。可改变和不可改变的危险因素通过不同的机制影响内皮细胞并导致内皮功能障碍的发生。内皮功能障碍是心血管疾病病理生理机制的基础,可引起血小板的过度活化和过度聚集,从而导致缺血性并发症的发生。尽管我们有大量的抗血小板和抗凝药物用于预防和治疗缺血性后果,但与药物治疗相关的副作用每年都在增加。抗血小板治疗的“金标准”——阿司匹林在一级和二级预防以及心血管疾病的治疗中逐渐失去了作用和重要性,因为出血主要发生在70岁以下、患有糖尿病或处于心血管疾病低危和轻度风险组的患者身上。这就是为什么开发更新、更安全、可能更少出血并发症的物质已成为现代医学的一项重要任务。从这个角度来看,植物基制剂含有丰富的多酚类物质,特别是花青素和黄酮类化合物,由于其抗血小板作用的多种作用机制,可以作为有效的和有前途的来源。多酚类物质的每一种作用机制都指向血小板聚集的不同阶段。本文就抗血小板活性药物的作用机制和副作用、开发新型安全抗血小板剂型的植物来源以及开发最佳药物剂型的技术途径进行了综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
New approaches of antiplatelet therapy in the prevention of cardiovascular diseases
Cardiovascular diseases are considered to be the leading cause of mortality in the world.Modifiable and non modifiable risk factors with different mechanisms affect the endothelial cells and lead to development of endothelial dysfunction. Endothelial dysfunction as a cornerstone of cardiovascular diseases’ pathophysiological mechanisms, causes overactivation and over aggregation of platelets resulting in the development of ischemic complications.Though we have huge arsenal of antiplatelet and anticoagulant drugs used for prevention and treatment of ischemic consequences, there is an increase of annual cases of side effects associated with pharmacotherapy.The “gold standard” of antiplatelet therapy - Aspirin gradually loses its role and importance in the primary and secondary prevention, as well as at the treatment of cardiovascular diseases due to the haemorrhage mostly on those patients who are under 70, have diabetes or are in the low and mild risk group of cardiovascular disease.That is why the development of newer and safer substances with possible less hemorrhagic complications has become an important task of modern medicine.In this point of view the plant based agents, containing rich composition of polyphenolic substances, particularly anthocyanins and flavonoids, could serve as potent and promising sources due to their antiplatelet effects, which is conditioned with several action mechanisms.Each action mechanism of polyphenolic substances is directed to the different phases of platelet aggregation. In this paper we have discussed the mechanisms and side effects of antiplatelet drugs with proven activity, the plants as a source for developing new and safe antiplatelet dosage forms and the technological ways to develop optimal drug dosage forms.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信