用于组织表征的空间蛋白质组学数据的分析和可视化

C. Fuchsberger, H. Hübl, G. Schäfer, A. Pelzer, G. Bartsch, H. Klocker, Nicola Barbarini, R. Bellazzi, W. Wieder, G. Bonn
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引用次数: 1

摘要

组织切片的空间蛋白质组学分析提供了蛋白质和肽的原位分子分析。这些高维数据立方体的分析和可视化具有挑战性。我们提出了一种基于新开发的特征识别和约简算法的方法。为了证明我们方法的有效性,我们用一种基于核密度的聚类算法分析了前列腺癌组织切片。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis and Visualization of Spatial Proteomic Data for Tissue Characterization
Spatial proteomic profiling of tissue sections provides in situ molecular analysis of proteins and peptides. Analysis and visualization of these high-dimensional data cubes is challenging. We present a methodology for this task based on a novel developed algorithm for the feature identification and reduction step. To show the validity of our approach, we analyzed prostate cancer tissue sections with an adapted kernel-density based clustering algorithm.
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