调节子宫颈癌细胞的生物活性化合物的药理学评价

M. Salinas-Santander, Patricia Álvarez-Ortiz, J. Valdés, R. Rodríguez‐Herrera, A. Zugasti-Cruz, R. Rangel-Zertuche, Victor de Jesus Suarez Valencia, Antonio Morlett-Chávez
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引用次数: 1

摘要

癌症一直是一个公共健康问题,导致了很多人死亡。然而,尽管宫颈癌的诊断和治疗取得了进展,妇女仍在与这种疾病作斗争。此外,这些患者的疗效和特异性有限,不良反应,耐药,治疗费用高。目前,一些研究已经证明了被称为生物活性化合物的天然产物对宫颈癌细胞系的有效性。生物活性化合物,包括多酚和酚酸或类黄酮等,具有抗氧化和促氧化特性。这些化合物可能具有抗氧化和促氧化的作用,具有较强的特异性和有效性。促氧化活性阻碍了与引发癌症的不同信号通路相关的生长因子。虽然,通常这类化合物有助于调控宫颈癌细胞的凋亡。本章的目的是回顾生物活性化合物如何影响信号通路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pharmacology Evaluation of Bioactive Compounds that Regulate Cervical Cancer Cells
Cancer has been a public health problem that has gained a lot of death. However, in spite of the advances in the diagnosis and treatment of cervical cancer, women follow the struggle versus this disease. Also, those patients suffer from limited efficacy and specificity, undesirable effects, drug resistance, and a high cost of treatments. Currently, several studies have demonstrated the efficiency of natural products, called bioactive compounds, against cervical cancer cell lines. Bioactive compounds, including polyphenols and phenolic acids or flavonoids, etc., have antioxidant and pro-oxidant properties. These compounds are efficacy and show high specificity because probably they act as anti-oxidant and pro-oxidant. The pro-oxidant activity obstructs growth factors related to different signalling pathways that trigger cancer. Although, usually this kind of compounds helps for dispatching the apoptosis in cervical cancer cell. The aim of this chapter is reviewing how bioactive compounds affect the signalling pathways.
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