中度跑步机运动对大鼠肝脏脂质代谢的影响

M. Hamada, S. Khater, Amany Behairy, Reham Behairy, A. Arisha, S. Shalaby
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引用次数: 0

摘要

几个复杂的因素导致大量体脂的积累,以及能量摄入和输出之间的差异。一般来说,体重的任何增加都可以归因于每日食物摄入量的增加和能量消耗的减少。适度运动可以实现多种功能,包括保持最佳体重和肌肉质量,减少腹部脂肪和增加脂质分解代谢。然而,所涉及的确切分子机制仍未得到充分研究。我们的研究主要是评估适度的跑步机运动对机体代谢的影响,特别参考肝脏脂质代谢。体重200±20 gm的成年雄性Sprague Dawley大鼠20只,随机分为久坐组和运动组。运动方案持续20分钟/ 5次/周,共4周。虽然体重、胰岛素和皮质酮水平没有明显变化,但空腹血糖和血清瘦素水平明显下降(分别为81.06%和75.49%)。当前运动方案显著提高了血清高密度脂蛋白(HDL-c)水平(127.56%),显著降低了血清三酰甘油(TAG)、低密度脂蛋白(LDL-c)和极低密度脂蛋白(VLDL-c)水平(分别为75.50%、62.83%和74.48%)。此外,跑步机运动显著上调肝脏乙酰辅酶a氧化酶(ACO)和肉毒碱棕榈酰辅酶a转移酶1 (CPT1)表达(分别为173%和148%),显著下调肝脏乙酰辅酶a羧化酶(ACC)表达(52%),但不下调脂肪酸合成酶(FAS) mRNA表达。总的来说,这些结果表明适度的跑步机运动对肝脏脂质代谢有有益的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Moderate Treadmill Exercise on Hepatic Lipid Metabolism in Rats
Several and complex factors cause accumulation of large amounts of body fat as well as a disparity between energy intake and output. Generally, any increase in bodyweight can be attributed to the elevation in daily food intake and the reduction in energy expenditure. Several functions could be achieved by moderate exercise including maintaining an optimum body weight and muscle mass, lowering abdominal fat and increasing lipid catabolism. However, the exact molecular mechanisms involved remain understudied. Our study was designed mainly to evaluate the influence of moderate treadmill exercise on body metabolism with special reference to hepatic lipid metabolism. Twenty adult male Sprague Dawley rats weighting 200±20 gm were randomly assigned to either sedentary or exercised groups. The exercise protocol lasted for 20 mins/ 5 times / week along 4 weeks. Although no significant changes in body weight, insulin and corticosterone levels, there was a significant decrease in fasting blood glucose and serum leptin levels (81.06%and 75.49% respectively). The current exercise regime significantly increased serum high density lipoprotein (HDL-c) level (127.56%) and significantly decreased serum triacylglycerol (TAG), low density lipoprotein (LDL-c) and very low-density lipoprotein (VLDL-c) levels (75.50%, 62.83% and 74.48% respectively). Also, treadmill exercise significantly upregulated the hepatic expression of acetyl-CoA oxidase (ACO) and carnitine palmitoyl CoA transferase 1 (CPT1) (173% and 148% respectively) as well as significantly downregulated the hepatic acetyl-CoA carboxylase (ACC) (52%) but not fatty acid synthase (FAS) mRNA expression. Overall, these results suggest a beneficial effect of moderate treadmill exercise hepatic lipid metabolism.
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