4.2 SPAAC和SPANC在生命科学中的应用

Click Chemistry Pub Date : 1900-01-01 DOI:10.1055/sos-sd-235-00184

L. J. N. Janssen, D. Blanco‐Ania

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引用次数: 0

摘要

采用生物正交、菌株促进叠氮-炔环加成反应(SPAAC)和菌株促进炔-硝基环加成反应(SPANC)进行偶联，具有较高的亲和力和特异性。与铜催化的细胞毒性环加成相反，SPAAC和SPANC在生物环境中都是惰性的。本章回顾了自2004年Bertozzi等人首次发表生物正交反应以来，SPAAC和SPANC在生命科学领域的发展和应用。

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4.2 Applications of SPAAC and SPANC in Life Sciences

The bioorthogonal, strain-promoted azide–alkyne cycloaddition (SPAAC) and the strain-promoted alkyne–nitrone cycloaddition (SPANC) reactions have been used for conjugation with high affinity and specificity. In contrast to the cytotoxic copper-catalyzed cycloaddition, both SPAAC and SPANC are inert in biological environments. This chapter reviews the developments and applications of SPAAC and SPANC in life sciences reported since 2004, when Bertozzi et al. published the first bioorthogonal reaction.

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Click Chemistry

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