妊娠晚期高血压和先兆子痫患者血清尿酸水平与围产期结局的关系

F. Nesa, F. Chowdhury, B. Yasmeen, N. Begum, A. Das
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摘要

背景:先兆子痫与产妇和新生儿并发症有关。有研究表明,尿酸升高可能对子痫前期有预测作用。一些研究已经证明了升高的母体血清尿酸水平和不良的母体和胎儿结局之间的关系。本研究旨在探讨妊娠晚期高血压和先兆子痫(PE)患者血清尿酸水平与围产期结局的关系。方法:于2017年7月至2018年6月在达卡医学院附属医院妇产科进行病例对照研究。有目的地选择在达卡医学院附属医院妇产科就诊的100名妊娠晚期孕妇作为研究对象。其中50例诊断为子痫前期患者,年龄18-35岁,50例正常健康年龄匹配的孕妇作为对照。通过病史、临床检查和相关实验室调查排除既往存在高血压、糖尿病和肾脏疾病的孕妇。结果:正常血压组血尿酸均值为4.49±1.72 mg/dl,子痫前期组血尿酸均值为7.03±1.89 mg/dl。子痫前期组血清尿酸显著高于正常血压组(p<0.05)。结果:正常血压组48例(96.0%),子痫前期组41例(82.0%)。高血压组新生儿早期死亡1例(2.0%),先兆子痫组新生儿早期死亡4例(8.0%)。正常血压组死产1例(2.0%),子痫前期组死产5例(10.0%)。结论:高尿酸血症是子痫前期最基本、最可靠的观察指标。而循环尿酸浓度升高在PE患者中并不均匀。但高尿酸血症存在于子痫前期妇女的一个子集中,她们有更高的母胎并发症风险。因此,血清尿酸浓度的测量似乎是一个有用的测试,以预测母体和胎儿并发症的先兆子痫妇女。《北方国际医学院学报》2019年7月1日第11卷第419-422页
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum uric acid level between normotensive and pre-eclamptic patients in third trimester of pregnancy and perinatal outcome
Background : Preeclampsia is associated with maternal and neonatal complications. It has been indicated that increased uric acid might have a predictive role on preeclampsia. Several studies have demonstrated a relation between elevated maternal serum uric acid levels and adverse maternal and fetal outcome. The aim of this study was to find out the association of serum uric acid level between normotensive and pre-eclamptic (PE) patients in third trimester of pregnancy and perinatal outcome. Methodology : A case control study was conducted in the department of the Obstetrics and Gynaecology in Dhaka Medical College Hospital from July 2017 to June 2018. A total number of 100 pregnant women in third trimester of pregnancy attending in Obstetrics and Gynaecology department of Dhaka Medical College Hospital were selected purposively as study subjects. Among them 50 diagnosed cases of preeclampsia were selected as cases with age range of 18-35 years and 50 normal healthy age matched pregnant women as controls. Pregnant women with pre-existing hypertension, diabetes mellitus and renal disease were excluded from the study by history, clinical examination and relevant laboratory investigations. Results : The mean serum uric acid level was found 4.49±1.72 mg/dl in normotensive group and 7.03±1.89 mg/dl in preeclampsia group. Serum uric acid was significantly higher (p<0.05) in pre-eclampsia group than normotensive group. Regarding outcome take home as alive neonate was found 48(96.0%) in normotensive group and 41(82.0%) in preeclampsia group. Early neonatal death was 1(2.0%) in normotensive and 4(8.0%) in pre-eclampsia group. Still birth was 1(2.0%) and 5(10.0%) in normotensive and pre-eclampsia group respectively. Conclusion : Hyperuricemia is most basic and reliable observations in pre-eclamptic pregnancies. While elevated concentrations of circulating uric acid are not uniformly increased in every woman with PE. But hyperuricemia is found in a subset of pre-eclamptic women who had higher risk for maternal and fetal complications. Therefore, measurement of serum uric acid concentration seems to be a useful test to predict maternal and fetal complications in a women with preeclampsia. Northern International Medical College Journal Vol. 11 No. 1 July 2019, Page 419-422
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