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Phoenix Medical Journal Pub Date : 2023-03-20 DOI:10.38175/phnx.1222179

Kadir Arslan, A. Şahin

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摘要

前言:本研究旨在鉴定2019冠状病毒病大流行前和期间某三级中心ICU住院患者血培养分离的微生物种类，并调查其抗生素敏感性。材料与方法:将2019年3月15日至2021年3月15日COVID-19大流行前后两年在ICU住院的患者分为两组，回顾性评价其血培养。对分离的微生物及其药敏进行了分析。结果:共分析1282例患者血培养，组间人口学数据相似。39.6% (n=202)的患者在大流行前检测到血培养物生长，41% (n=317)的患者在大流行期间检测到血培养物生长。革兰氏阳性菌占71.3%，革兰氏阴性菌占21.6%，念珠菌占7.1%。在大流行期间，克雷伯氏菌在血培养中显著升高，肠球菌在血培养中显著降低。在COVID-19期间，金黄色葡萄球菌、克雷伯氏菌、大肠杆菌、肠杆菌和假单胞菌对抗生素的敏感性虽无显著下降，但对凝固酶阴性葡萄球菌(CNS)对替柯planin和利奈唑胺的敏感性下降有统计学意义。在大流行期间，57.6% (n=172)的患者呈COVID-19阳性。在covid -19阳性患者中，虽然念珠菌含量明显升高，但抗真菌敏感性未见下降。结论:在大流行期间，革兰氏阳性和革兰氏阴性微生物的抗生素敏感性下降。虽然在covid -19阳性患者中念珠菌感染率显著升高，但其抗真菌敏感性并未下降。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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COVID-19 Pandemisi Öncesi ve Döneminde Yoğun Bakım Ünitesinde Takip Edilen Hastaların Kan Kültürü İzolatlarının Tür Dağılımı ve Antibiyotik Duyarlılıklarının Değerlendirilmesi: Retrospektif, Tek Merkez Analizi

Introduction: This study aims to identify the microorganism species isolated from blood cultures of patients hospitalized in the ICU of a tertiary center before and during the COVID-19 pandemic and to investigate their antibiotic susceptibility. Material and Methods: Patients hospitalized in the ICU two years before and after the COVID-19 pandemic between March 15, 2019, and March 15, 2021, were divided into two groups, and their blood cultures were evaluated retrospectively. Isolated microorganisms and their antibiotic susceptibility were analyzed. Results: A total of 1282 patients' blood cultures were analyzed, and demographic data were similar between groups. Blood culture growth was detected in 39.6% (n=202) of the patients in the pre-pandemic period and 41% (n=317) in the pandemic period. Gram-positive bacteria were isolated in 71.3%, gram-negative bacteria in 21.6%, and Candida spp. in 7.1% of the population. Klebsiella spp. was significantly higher, and Enterococcus spp. was significantly lower in blood cultures during the pandemic. In the COVID-19 period, although not significant, a decrease in antibiotic susceptibility was detected for Staphylococcus aureus, Klebsiella spp., E.coli, Enterobacter spp. and Pseudomonas spp. There was a statistically significant decrease in susceptibility to teicoplanin and linezolid in coagulase-negative staphylococci (CNS). During the pandemic, 57.6% (n=172) of the patients were positive for COVID-19. In COVID-19-positive patients, while Candida spp. was significantly higher, no decrease in antifungal susceptibility was detected. Conclusion: During the pandemic, antibiotic susceptibility to gram-positive and gram-negative microorganisms decreased. Although there was a significant increase in Candida spp. rates in COVID-19-positive patients, there was no decrease in their antifungal susceptibility.

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Phoenix Medical Journal

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