ICGdb:一个整合的癌症基因组数据库

Nilubon Kurubanjerdjit
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引用次数: 0

摘要

ICGdb的主要目标是:1)为未来癌症生物标志物和有效药物的发现提供一个从各种资源收集当前癌症基因组信息的网站;2)收集我们当前和未来研究工作的发现。本研究的主要贡献有两点:首先,ICGdb是通过整合30多种肿瘤或疾病的基因组学基本数据片段,包括基因组学和表观基因组学信息构建的。我们当前和未来研究工作的输入数据集将从该数据库中提取。其次,通过网络聚类方法鉴定了6种肿瘤类型的生物标志物蛋白复合物,并对其靶向药物进行了研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ICGdb: An Integrative Cancer Genomic Database
The major goals of the ICGdb are 1) to provide a one site of current genomic cancer information gathering from various resources for the future studies on the discovering of cancer biomarker and efficient drugs and 2) to collect findings from our current and future research works. There are two main contributions in this study, firstly, the ICGdb was constructed by integrating essential pieces of genomic data of more than 30 tumors or diseases including genomic and epigenomics information. The input datasets for our current and future research works will be extracted from this database. Secondly, protein complexes as biomarker of the six tumor types were identified by network clustering approach and the target drugs were also investigated.
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