{"title":"伦理困境中的生命线:脐带血作为胚胎干细胞的替代品","authors":"Ian Rogers Ph.D. , Robert F. Casper M.D.","doi":"10.1016/j.sram.2004.04.006","DOIUrl":null,"url":null,"abstract":"<div><p><span>Embryonic stem (ES) cells are capable of unlimited self-renewal and have the ability to give rise to all tissue types in the body. Recently, tissue-specific stem cells such as bone marrow cells have also been found to be capable of multilineage differentiation into cells of various nonblood tissues. Umbilical cord blood hematopoietic stem cells<span><span> have been shown to be as effective as bone marrow stem cells for rebuilding the </span>hematopoietic system<span> and differentiating into nonblood cell types. This observation raises the exciting possibility of replacing human ES cells for tissue and cell therapeutics with umbilical cord blood hematopoietic stem cells that are normally discarded with the placenta after delivery. </span></span></span><span><figure><span><img><ol><li><span>Download : <span>Download full-size image</span></span></li></ol></span><span><span><p><span>Fig 1</span>. </p></span></span></figure></span></p></div>","PeriodicalId":89480,"journal":{"name":"Sexuality, reproduction & menopause","volume":"2 2","pages":"Pages 64-70"},"PeriodicalIF":0.0000,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.sram.2004.04.006","citationCount":"3","resultStr":"{\"title\":\"Lifeline in an ethical quagmire: umbilical cord blood as an alternative to embryonic stem cells\",\"authors\":\"Ian Rogers Ph.D. , Robert F. Casper M.D.\",\"doi\":\"10.1016/j.sram.2004.04.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Embryonic stem (ES) cells are capable of unlimited self-renewal and have the ability to give rise to all tissue types in the body. Recently, tissue-specific stem cells such as bone marrow cells have also been found to be capable of multilineage differentiation into cells of various nonblood tissues. Umbilical cord blood hematopoietic stem cells<span><span> have been shown to be as effective as bone marrow stem cells for rebuilding the </span>hematopoietic system<span> and differentiating into nonblood cell types. This observation raises the exciting possibility of replacing human ES cells for tissue and cell therapeutics with umbilical cord blood hematopoietic stem cells that are normally discarded with the placenta after delivery. </span></span></span><span><figure><span><img><ol><li><span>Download : <span>Download full-size image</span></span></li></ol></span><span><span><p><span>Fig 1</span>. </p></span></span></figure></span></p></div>\",\"PeriodicalId\":89480,\"journal\":{\"name\":\"Sexuality, reproduction & menopause\",\"volume\":\"2 2\",\"pages\":\"Pages 64-70\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2004-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.sram.2004.04.006\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sexuality, reproduction & menopause\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1546250104001070\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sexuality, reproduction & menopause","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1546250104001070","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Lifeline in an ethical quagmire: umbilical cord blood as an alternative to embryonic stem cells
Embryonic stem (ES) cells are capable of unlimited self-renewal and have the ability to give rise to all tissue types in the body. Recently, tissue-specific stem cells such as bone marrow cells have also been found to be capable of multilineage differentiation into cells of various nonblood tissues. Umbilical cord blood hematopoietic stem cells have been shown to be as effective as bone marrow stem cells for rebuilding the hematopoietic system and differentiating into nonblood cell types. This observation raises the exciting possibility of replacing human ES cells for tissue and cell therapeutics with umbilical cord blood hematopoietic stem cells that are normally discarded with the placenta after delivery.
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