{"title":"HMNPPID:与人类恶性肿瘤相关的蛋白-蛋白相互作用数据库","authors":"Qingqing Li, Zhihao Yang, Zhehuan Zhao, Ling Luo, Zhiheng Li, Lei Wang, Yin Zhang, Hongfei Lin, Jian Wang, Yijia Zhang","doi":"10.1109/BIBM.2018.8621402","DOIUrl":null,"url":null,"abstract":"Protein-protein interactions (PPIs) play a key role in varies aspects of the structural and functional organization of the cell. Knowledge about them unveils the molecular mechanisms of biological processes. At the same time, the PPIs related to human malignant neoplasms can shed light on the biology behind these neoplasms. However, there is no such PPI database available so far. We constructed a database of protein-protein interactions associated with human malignant neoplasms, named HMNPPID, which contains the PPIs of 171 kinds of human malignant neoplasms. HMNPPID provides healthcare professionals with the PPIs of specific malignant neoplasm without digging into amounts of biomedical literatures, which significantly improves the efficiency of researches on the PPIs of malignant neoplasms. In addition, a visualization program, VisualPPI, is provided to facilitate the analysis of the specific PPI network for a malignant neoplasm.","PeriodicalId":108667,"journal":{"name":"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","volume":"75 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"HMNPPID: A Database of Protein-protein Interactions Associated with Human Malignant Neoplasms\",\"authors\":\"Qingqing Li, Zhihao Yang, Zhehuan Zhao, Ling Luo, Zhiheng Li, Lei Wang, Yin Zhang, Hongfei Lin, Jian Wang, Yijia Zhang\",\"doi\":\"10.1109/BIBM.2018.8621402\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Protein-protein interactions (PPIs) play a key role in varies aspects of the structural and functional organization of the cell. Knowledge about them unveils the molecular mechanisms of biological processes. At the same time, the PPIs related to human malignant neoplasms can shed light on the biology behind these neoplasms. However, there is no such PPI database available so far. We constructed a database of protein-protein interactions associated with human malignant neoplasms, named HMNPPID, which contains the PPIs of 171 kinds of human malignant neoplasms. HMNPPID provides healthcare professionals with the PPIs of specific malignant neoplasm without digging into amounts of biomedical literatures, which significantly improves the efficiency of researches on the PPIs of malignant neoplasms. In addition, a visualization program, VisualPPI, is provided to facilitate the analysis of the specific PPI network for a malignant neoplasm.\",\"PeriodicalId\":108667,\"journal\":{\"name\":\"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)\",\"volume\":\"75 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/BIBM.2018.8621402\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/BIBM.2018.8621402","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
HMNPPID: A Database of Protein-protein Interactions Associated with Human Malignant Neoplasms
Protein-protein interactions (PPIs) play a key role in varies aspects of the structural and functional organization of the cell. Knowledge about them unveils the molecular mechanisms of biological processes. At the same time, the PPIs related to human malignant neoplasms can shed light on the biology behind these neoplasms. However, there is no such PPI database available so far. We constructed a database of protein-protein interactions associated with human malignant neoplasms, named HMNPPID, which contains the PPIs of 171 kinds of human malignant neoplasms. HMNPPID provides healthcare professionals with the PPIs of specific malignant neoplasm without digging into amounts of biomedical literatures, which significantly improves the efficiency of researches on the PPIs of malignant neoplasms. In addition, a visualization program, VisualPPI, is provided to facilitate the analysis of the specific PPI network for a malignant neoplasm.
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