Characterizing the spatio-temporal dynamics of the epileptogenic process with nonlinear EEG analyses

In this overview we present our work investigating the spatio-temporal dynamics of the epileptogenic process using time series analysis techniques derived from the theory of nonlinear dynamics. Apart from a localization of epileptic foci in different anatomical locations during the seizure-free interval we discuss possibilities for seizure prediction, a field that represents one of the greatest challenges in epileptology. The unequivocal definition of a pre-seizure state of a sufficient length would enable investigation of basic mechanisms leading to seizure initiation in humans and provide a basis for the development of adequate seizure prevention strategies.