Atrophic sites rehabilitation by use of dental implants and bone regeneration: an analisys of novel tissue engineering clinical approach

The introduction of the principles of tissue engineering has certainly changed the clinical approach in the treatment of atrophic implant site. In the study of factors that influence the clinical and biological outcome, a primary role is played by signaling molecules, the scaffold used and the autologous cells, that make up a symbolic triangle of the key elements of tissue engineering. From the results of the preclinical studies in the literature 3-4-5-6-, it was planned a prospective study on the rehabilitation of the atrophic implant site by tissue engineering technique with TiUnite surface implants. It was therefore tried to assess the regenerative potential in the execution of the guided bone regeneration technique of an allograft soaked with PDGF_BB growth factor recombined without application of autologous tissue.