黑孜然种子(Nigella sativa)在炎性疾病中的治疗潜力和有前途的分子机制

Hager K. Rashwan, Shahenda Mahgoub, Nermeen Z Abuelezz, Hatem K. Amin
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引用次数: 1

摘要

炎症是抵抗有害刺激的基本防御机制。然而,不受控制的炎症机制最终导致紊乱的反应,导致多种严重疾病。除了常见的合成药物外,人们对优化天然产品的使用越来越感兴趣,作为治疗或保护炎症性疾病的补充剂。黑孜然种子(BCS),或黑孜然(黑孜然科),在中东,远东和西亚被广泛用作保健草药。BCS是植物化学物质的丰富来源,研究已经报道了它对多种与炎症通路中断相关的代谢、增殖、呼吸和神经疾病的有希望的作用。本文综述了BCS对各种炎症疾病的作用的最新综合评估,并强调了BCS的生物活性成分在炎症和氧化应激途径中的作用。此外,它概述了通过有效的药物制剂提高治疗活性的未来可能性。对1998年至2023年间发表的国际研究的深入分析表明,BCS的生物活性成分通过调节炎症和炎症疾病中关键的氧化应激参与者,具有良好的抗炎潜力。因此,BCS的生物活性成分可以通过纳米掺入等最新技术进一步提高,以改善炎症性疾病的管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Black Cumin Seed (Nigella sativa) in Inflammatory Disorders: Therapeutic Potential and Promising Molecular Mechanisms
Inflammation is an essential defense mechanism against harmful stimuli. However, uncontrolled inflammatory mechanisms culminate in disturbed responses that contribute to multiple serious diseases. Besides common synthetic drugs, there is a growing interest in optimizing the use of natural products as therapeutic or protective supplements against inflammatory disorders. Black cumin seed (BCS), or Nigella sativa (Family Ranunculaceae), is widely used as a health-supportive herb in the Middle East, Far East and West Asia. BCS is a rich source of phytochemicals, and studies have reported its promising effects against a variety of metabolic, proliferative, respiratory, and neurological disorders associated with disrupted inflammatory pathways. This review presents an updated comprehensive assessment of BCS’s effects against various inflammatory disorders and highlights the role of BCS’s bioactive constituents in inflammation and oxidative stress pathways. Moreover, it outlines the future possibilities for enhancing therapeutic activity through efficient pharmaceutical formulations. Thorough analysis of international research studies published between the years 1998 and 2023 reveals the promising anti-inflammatory potential of BCS’s bioactive constituents through modulating inflammation and crucial oxidative stress players in inflammatory disorders. Thus, the bioactive constituents of BCS can be further boosted by updated technologies such as nano-incorporation for the improved management of inflammatory diseases.
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