{"title":"一种新型酞菁锌光动力疗法:一种治疗肝细胞癌的创新方法","authors":"Racheal O. Ogbodu, B. Nitzsche, M. Höpfner","doi":"10.1117/12.2522169","DOIUrl":null,"url":null,"abstract":"The photodynamic activity (PDT) of Tetra triethyleneoxysulfonyl zinc phthalocyanine (ZnPc) was studied on HepG2 and Huh-7 cells a typical example of hepatocellular carcinoma (HCC). HCC cells showed a dose dependent uptake of ZnPc. Photo-activation of ZnPc (0.5-5 µM) in HCC cells revealed strong PDT effects, leading to a dose-dependent decrease of cancer cells without any sign of re-proliferation and a dose-dependent increase in caspase-3-activity. By contrast, non-photoactivated ZnPc did not induce any cytotoxicity. The formation of ROS and free radical detected in the cytoplasm/nucleus of HCC cells and the expression of apoptotic proteins confirm the apoptotic mode of cell death.","PeriodicalId":267589,"journal":{"name":"World Congress of the International Photodynamic Association","volume":"14 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Photodynamic therapy with a novel zinc phthalocyanine: an innovative approach to hepatocellular carcinoma treatment\",\"authors\":\"Racheal O. Ogbodu, B. Nitzsche, M. Höpfner\",\"doi\":\"10.1117/12.2522169\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The photodynamic activity (PDT) of Tetra triethyleneoxysulfonyl zinc phthalocyanine (ZnPc) was studied on HepG2 and Huh-7 cells a typical example of hepatocellular carcinoma (HCC). HCC cells showed a dose dependent uptake of ZnPc. Photo-activation of ZnPc (0.5-5 µM) in HCC cells revealed strong PDT effects, leading to a dose-dependent decrease of cancer cells without any sign of re-proliferation and a dose-dependent increase in caspase-3-activity. By contrast, non-photoactivated ZnPc did not induce any cytotoxicity. The formation of ROS and free radical detected in the cytoplasm/nucleus of HCC cells and the expression of apoptotic proteins confirm the apoptotic mode of cell death.\",\"PeriodicalId\":267589,\"journal\":{\"name\":\"World Congress of the International Photodynamic Association\",\"volume\":\"14 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-08-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World Congress of the International Photodynamic Association\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1117/12.2522169\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Congress of the International Photodynamic Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1117/12.2522169","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Photodynamic therapy with a novel zinc phthalocyanine: an innovative approach to hepatocellular carcinoma treatment
The photodynamic activity (PDT) of Tetra triethyleneoxysulfonyl zinc phthalocyanine (ZnPc) was studied on HepG2 and Huh-7 cells a typical example of hepatocellular carcinoma (HCC). HCC cells showed a dose dependent uptake of ZnPc. Photo-activation of ZnPc (0.5-5 µM) in HCC cells revealed strong PDT effects, leading to a dose-dependent decrease of cancer cells without any sign of re-proliferation and a dose-dependent increase in caspase-3-activity. By contrast, non-photoactivated ZnPc did not induce any cytotoxicity. The formation of ROS and free radical detected in the cytoplasm/nucleus of HCC cells and the expression of apoptotic proteins confirm the apoptotic mode of cell death.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
