Carbon Monoxide Poisoning Associated Hyperlactatemia

We read with great interest the article titled “TThe Role of SII and SIRI Values in Predicting the Severity of CO Poisoning in the Emergency Department” prepared by Acar and Ertekin, published in the first issue of 2023 of your journal. We thank the authors and the editorial board for the article discussing the relationship between the severity of CO poisoning and combined hematological indices such as systemic immune inflammation index, systemic inflammatory response index and systemic inflammation total index, which have been defined in the last decade in the literature in carbon monoxide (CO) poisoning. However, we would like to point out a few points that will contribute to the discussion of the article on the pathogenesis of hyperlactatemia and the hemodynamic impact in CO poisoning, which the authors used to describe severe poisoning.