Effect of Magnesium Sulphate and Clonidine on Propofol Consumption, Hemodynamics and Postoperative Recovery Using Bispectral Index (BIS) In Elective Surgeries"

The purpose of this placebo-controlled, double-blind study was to see how magnesium sulphate and clonidine affected perioperative hemodynamics, propofol consumption, and postoperative recovery. Ninety ASA I–II patients undergoing elective laparoscopic surgery were randomized into three groups. Group M Patients received Inj. magnesium sulphate (40mg/kg) in 20 ml saline infused over a period of 15 minutes before induction. Group C received Patients received Inj. Clonidine (3mcg/kg) before induction. The Group S (Control group) received 20ml normal saline over 15mind before induction. Propofol was used for induction of anaesthesia and for maintenance propofol infusion was used which was adjusted as per bispectral index along with intermittent fentanyl bolus and vecuronium as muscle relaxant According to type of data, different tests of statistical significance like Chi-square test, Kruskal Wallis test and one-way ANOVA were used. In the presence of magnesium sulphate and clonidine, propofol induction was rapid. The time it took for BIS to reach 60 was significantly shorter in groups M and C (P0.0001), and compared to clonidine and control group post-operative recovery was more delayed in magnesium sulphate group (P0.0001). There was no statistically significant difference between the groups in heart rate or arterial blood pressure. Preoperative use of magnesium sulphate and clonidine resulted in significant reduction in propofol requirements for induction as well as for maintenance (P0.0001).To conclude use of magnesium sulphate caused delayed recovery and hypotension and bradycardia was observed with clonidine, but both can be used as adjuvants with caution.