表皮生长因子与硅橡胶支架对慢性中耳炎鼓膜穿孔的影响

V. Bhat, S. Desai, Darshan Hiremath
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引用次数: 0

摘要

慢性中耳炎的负担仍然很高,特别是在发展中国家。手术鼓膜成形术被认为是治疗鼓膜穿孔的金标准,对这种矫正手术的需求也在增长。因此,有必要创新更简单的替代办公程序,以节省精力、时间、等待时间和支出。材料与方法对某三级转诊医院84例黏膜慢性中耳炎患者进行前瞻性研究。所有患者均行咽鼓管功能检查、诊断性鼻内窥镜检查和纯音听力学检查。内镜下评估穿孔的大小。首先用硝酸银溶液对所有射孔进行清洗。橡胶片放置在穿孔的内侧和外侧,中间夹有表皮生长因子凝胶。随访3个月。结果根据第1个月和第3个月的治疗效果,将穿孔分为愈合、部分愈合和未愈合三组。完全愈合和部分愈合的穿孔被认为是“成功”的,在本研究中发现79%的穿孔是“成功”的。治疗状态与麻醉类型有显著相关性。然而,疾病分期、穿孔大小和手术时间对愈合情况没有影响。结论表皮生长因子硅橡胶增强鼓膜成形术是一种简单、有效、经济的治疗慢性中耳炎的替代方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Epidermal Growth Factor with Silastic Scaffold on Tympanic Membrane Perforations of Chronic Otitis Media
Abstract Aims The burden of chronic otitis media continues to be high, especially in developing countries. The demand for corrective procedure of surgical myringoplasty, which is considered the gold standard for tympanic membrane perforations, is also growing. Hence, there is a need to innovate simpler alternative office procedures that could save effort, time, waiting period, and expenditure. Materials and Methods This prospective study of 84 patients with mucosal chronic otitis media was undertaken in a tertiary referral hospital. All patients underwent eustachian tube function test, diagnostic nasal endoscopy, and pure tone audiometry. The size of the perforation was assessed endoscopically. All perforations were freshened first with silver nitrate solution. Silastic pieces were placed medial and lateral to the perforation with epidermal growth factor gel in between. Patients were followed up for 3 months. Results The perforations were classified into three groups (healed, partially healed, and nonhealed) based on the treatment response at the end of the first and third follow-up months. Completely healed and partially healed perforations were considered as “success” and were found to be 79% in this study. Significant association was found between healing status and type of anesthesia. However, the disease stage, size of perforation, and the duration of procedure did not affect the healing status. Conclusion Silastic enhanced myringoplasty with epidermal growth factor is a simple, effective, and economical procedure that can become an alternative to surgical myringoplasty for chronic otitis media.
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