用于免疫控制的纳米颗粒递送系统

2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04) Pub Date : 2004-08-25 DOI:10.1109/ICMENS.2004.109

J. Samuel, Praveen Elamanchili, M. Diwan, A. Haddadi, Anahita Dehmoobed

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引用次数: 0

摘要

设计了可生物降解的聚(D, l -乳酸-羟基乙酸)(PLGA)纳米颗粒，将抗原和免疫调节分子靶向树突状细胞。PLGA纳米颗粒被小鼠和人树突状细胞有效地吞噬。抗原与免疫刺激分子的纳米颗粒递送到树突状细胞导致抗原特异性免疫反应的诱导。或者，抗原和免疫抑制分子共同递送到树突状细胞可用于诱导免疫耐受。

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Nanoparticulate Delivery Systems for Control of Immunity

Biodegradable poly (D, L-lactic-co-glycolic acid) (PLGA) nanoparticles were designed to target antigens and immunomodulatory molecules to dendritic cells. PLGA nanoparticles were shown to be efficiently phagocytosed by murine and human dendritic cells. Nanoparticle delivery of antigens along with immunostimulatory molecules to dendritic cells resulted in induction of antigen-specific immune responses. Alternatively co-delivery of antigens and immunosuppressive molecules to dendritic cells may be used to induce immune tolerance.

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来源期刊

2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)

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