不同载体下铀-177在不同脏器组织中的放射性药物剂量分布

Hesham MH Zakaly, M. Mostafa, M. Zhukovsky
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引用次数: 6

摘要

177Lu是指一组镧系元素中的稀土元素。177Lu相对于其较短的时间跨度,几乎已经渗透到体内放射性核素治疗的各个领域,成为靶向放射性核素治疗中治疗性核素选择的重要关键之一。在靶向分子治疗中使用177Lu的兴趣日益增加,主要源于最近分子和细胞生物学的无与伦比的进展,其中包括靶向细胞表面受体的肽的使用,这些受体在肿瘤细胞表面过表达。因此,由于分子和细胞生物学的进步,使用177lu标记的放射性药物一直是引起研究人员兴奋的主要因素,并吸引了临床界的想象力。本文介绍了177Lu在健康人体器官和组织中吸收剂量的放射性药物比较。比较未标记的177Lu(离子形式)和标记的177Lu- mdp(亚甲基二膦酸盐)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Radiopharmaceutical dose distribution in different organs and tissues for Lu-177 with different carrier
177Lu refers to rare earth elements from a group of lanthanides. Relative to its short time span, 177Lu has virtually pervaded all areas of in vivo radionuclide therapy and becomes one of important keys for therapeutic radionuclides of choice for targeted radionuclide therapy. The rising interest in the use of 177Lu in targeted molecular therapies has primarily developed from recent unmatched advances in molecular and cell biology, which include the use of peptides targeted to cell surface receptors, which are overexpressed on the surface of tumour cells. Therefore, the use of 177Lu-labelled radiopharmaceuticals have been the major factors evoking excitement among researchers and capturing the imagination of the clinical community thanks to advances in molecular and cellular biology. In this work, radiopharmaceutical comparison for 177Lu absorbed dose in health human organs and tissues is presented. The comparison between unlabelled 177Lu (ionic form) and labelled with 177Lu-MDP (methylenediphosphonate) a...
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