基于综合医院非手术入院电子记录的院内死亡动态风险分类系统的验证

Lucimar Leão Gomes, F. Volpe
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引用次数: 0

摘要

目的:建立并验证一套适用于普通医院成人非手术病例的院内死亡风险分类系统。方法:选取米纳斯吉拉斯州5家公立综合医院非手术住院患者。步骤:采用logistic回归建立入院死亡预测模型;根据所选变量的独立效应建立严重程度指数,然后验证其预测指标入院期间院内死亡的能力;通过使用新的数据集对其进行挑战来验证预测尺度。结果:最终的多变量模型包括7个显著预测变量:年龄、性别、诊断相关组、指标入院医院、入住ICU、总住院时间和非计划手术。该模型具有良好的拟合和公平的判别性能(AUC=0.78)。新样本的时间验证也表现出足够的拟合,判别性能再次公平(AUC=0.76)。结论:一个动态的、临床有用的非手术住院患者院内死亡风险分类系统已经得到验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
VALIDATION OF A DYNAMIC RISK CLASSIFICATION SYSTEM FOR IN-HOSPITAL DEATH, BASED ON ELECTRONIC RECORDS OF NON-SURGICAL ADMISSIONS TO GENERAL HOSPITALS
Objective: To develop and validate a risk-classification system for in-hospital death, clinically useful for general hospital adult primarily non-surgical cases. Methods: Admissions for non-surgical conditions at 5 public general hospitals of Minas Gerais were included. Procedures: Build a predictive model for death during admission, using logistic regression; Create a severity index based on the independent effect of the selected variables, and then, validate its ability to predict in-hospital death during index admission; Validate the predictive scale by challenging it with a new dataset. Results: The final multivariate model included seven significant predictive variables: age, gender, diagnostic-related group, hospital of index admission, admission to the ICU, total length of stay, and unplanned surgical procedure. This model presented adequate fit and fair discriminative performance (AUC=0.78). Temporal validation with a new sample also presented an adequate fit, and the discriminative performance was again fair (AUC=0.76). Conclusions: A dynamic and clinically useful risk classification system for in-hospital death of non-surgical admissions has been validated.
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