Super-Resolution for Brain MR Images from a Significantly Small Amount of Training Data

article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at Abstract: We propose two essential techniques to effectively train generative adversarial network-based super-resolution networks for brain magnetic resonance images, even when only a small number of training samples are available. First, stochastic patch sampling is proposed, which in-creases training samples by sampling many small patches from the input image. However, sampling patches and combining them causes unpleasant artifacts around patch boundaries. The second proposed method, an artifact-suppressing discriminator, suppresses the artifacts by taking two-channel input containing an original high-resolution image and a generated image. With the introduction of the proposed techniques, the network achieved generation of natural-looking MR images from only ~40 training images, and improved the area-under-curve score on Alzheimer’s disease from 76.17% to 81.57%.