用无标签生物电子传感器检测标记物的单分子

2019 IEEE 8th International Workshop on Advances in Sensors and Interfaces (IWASI) Pub Date : 2019-06-01 DOI:10.1109/IWASI.2019.8791263

L. Torsi

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引用次数: 0

摘要

到目前为止，通过将大量配体汇集到单结合事件序列中，在纳米传感器上宿主的识别元件很少，可以实现无标记单分子检测。这种方法本质上无法在大量环境中感知线索。将细胞在物理极限下的感知能力概念化，通过高度填充的识别元件，一个毫米大小的场效应晶体管被用来检测单个分子。

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Single Molecule Detection of Markers with a Label-free Bio-Electronic Sensor

Label-free single-molecule detection has been achieved so far by funnelling a large number of ligands into a sequence of single-binding events with few recognition elements host on nanometric transducers. Such approaches are inherently unable to sense a cue in a bulk milieu. Conceptualizing cells’ ability to sense at the physical limit by means of highly-packed recognition elements, a millimetric sized field-effect-transistor is used to detect a single molecule.

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来源期刊

2019 IEEE 8th International Workshop on Advances in Sensors and Interfaces (IWASI)

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