N.C. Goomer, P.V. Kulkarni, A. Constantinescu, P. Antich, R.W. Parkey, J.R. Corbett
{"title":"苯基取代/浓缩四齿席夫碱与三甲基膦的锝-99m单阳离子混合配体配合物的合成与评价","authors":"N.C. Goomer, P.V. Kulkarni, A. Constantinescu, P. Antich, R.W. Parkey, J.R. Corbett","doi":"10.1016/0883-2897(92)90102-5","DOIUrl":null,"url":null,"abstract":"<div><p>Tc-99m monocationic mixed ligand complexes of phenyl substituted/condensed Schiff's bases, <em>N,N′</em>-ethylene-bis-(benzoylacetone imine) (L<sub>b</sub>) or <em>N,N′</em>-ethylene-bis-(salicylaldehyde imine) (L<sub>c</sub>) or <em>N,N′</em>-ethylene-bis-(2-hydroxyacetophenone imine) (L<sub>d</sub>) and trimethylphosphine were synthesized to determine the influence of the presence of a phenyl group in these tracers on their heart uptake in rats. A new formulation procedure using aq. β-hydroxypropylcyclodextrin (HPB) solution was developed for intravenous administration of nonpolar <sup>99m</sup>Tc complexes. Comparison of biodistribution data for the reference <sup>99m</sup>Tc complex from <em>N,N′</em>-ethylene-bis-(acetylacetone imine) and trimethylphosphine using HPB formulation and alternate formulation (0.9% saline) showed the same results. Biodistribution of the title <sup>99m</sup>Tc complexes, [<sup>99m</sup>Tc L<sub>b</sub> (PMe<sub>3</sub>)<sub>2</sub>]<sup>+</sup>, [<sup>99m</sup>Tc L<sub>c</sub> (PMe<sub>3</sub>)<sub>2</sub>]<sup>+</sup> and [<sup>99m</sup>Tc L<sub>d</sub> (PMe<sub>3</sub>)<sub>2</sub>]<sup>+</sup> showed heart-to-blood activity ratios of 1.7, 2.1 and 1.7, respectively, at 15 min post-injection in rats.</p></div>","PeriodicalId":14328,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","volume":"19 6","pages":"Pages 679-684"},"PeriodicalIF":0.0000,"publicationDate":"1992-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2897(92)90102-5","citationCount":"1","resultStr":"{\"title\":\"Synthesis and evaluation of technetium-99m monocationic mixed ligand complexes of phenyl substituted/condensed tetradentate schiff's bases and trimethylphosphine\",\"authors\":\"N.C. Goomer, P.V. Kulkarni, A. Constantinescu, P. Antich, R.W. Parkey, J.R. Corbett\",\"doi\":\"10.1016/0883-2897(92)90102-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Tc-99m monocationic mixed ligand complexes of phenyl substituted/condensed Schiff's bases, <em>N,N′</em>-ethylene-bis-(benzoylacetone imine) (L<sub>b</sub>) or <em>N,N′</em>-ethylene-bis-(salicylaldehyde imine) (L<sub>c</sub>) or <em>N,N′</em>-ethylene-bis-(2-hydroxyacetophenone imine) (L<sub>d</sub>) and trimethylphosphine were synthesized to determine the influence of the presence of a phenyl group in these tracers on their heart uptake in rats. A new formulation procedure using aq. β-hydroxypropylcyclodextrin (HPB) solution was developed for intravenous administration of nonpolar <sup>99m</sup>Tc complexes. Comparison of biodistribution data for the reference <sup>99m</sup>Tc complex from <em>N,N′</em>-ethylene-bis-(acetylacetone imine) and trimethylphosphine using HPB formulation and alternate formulation (0.9% saline) showed the same results. Biodistribution of the title <sup>99m</sup>Tc complexes, [<sup>99m</sup>Tc L<sub>b</sub> (PMe<sub>3</sub>)<sub>2</sub>]<sup>+</sup>, [<sup>99m</sup>Tc L<sub>c</sub> (PMe<sub>3</sub>)<sub>2</sub>]<sup>+</sup> and [<sup>99m</sup>Tc L<sub>d</sub> (PMe<sub>3</sub>)<sub>2</sub>]<sup>+</sup> showed heart-to-blood activity ratios of 1.7, 2.1 and 1.7, respectively, at 15 min post-injection in rats.</p></div>\",\"PeriodicalId\":14328,\"journal\":{\"name\":\"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology\",\"volume\":\"19 6\",\"pages\":\"Pages 679-684\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1992-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0883-2897(92)90102-5\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0883289792901025\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0883289792901025","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis and evaluation of technetium-99m monocationic mixed ligand complexes of phenyl substituted/condensed tetradentate schiff's bases and trimethylphosphine
Tc-99m monocationic mixed ligand complexes of phenyl substituted/condensed Schiff's bases, N,N′-ethylene-bis-(benzoylacetone imine) (Lb) or N,N′-ethylene-bis-(salicylaldehyde imine) (Lc) or N,N′-ethylene-bis-(2-hydroxyacetophenone imine) (Ld) and trimethylphosphine were synthesized to determine the influence of the presence of a phenyl group in these tracers on their heart uptake in rats. A new formulation procedure using aq. β-hydroxypropylcyclodextrin (HPB) solution was developed for intravenous administration of nonpolar 99mTc complexes. Comparison of biodistribution data for the reference 99mTc complex from N,N′-ethylene-bis-(acetylacetone imine) and trimethylphosphine using HPB formulation and alternate formulation (0.9% saline) showed the same results. Biodistribution of the title 99mTc complexes, [99mTc Lb (PMe3)2]+, [99mTc Lc (PMe3)2]+ and [99mTc Ld (PMe3)2]+ showed heart-to-blood activity ratios of 1.7, 2.1 and 1.7, respectively, at 15 min post-injection in rats.
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