有合并症的老年高血压患者维生素D水平与他汀类药物治疗的关系评估

K. Nyulas, Zsuzsánna Simon-Szabó, Z. Preg, S. Pál, Arundhati Sharma, T. Pál, M. Germán-Salló, E. Nemes-Nagy
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引用次数: 0

摘要

背景:他汀类药物长期应用于伴有血脂异常的高血压患者,可干扰维生素D代谢。超重/肥胖和2型糖尿病(DM)常与高血压相关。该研究的目的是评估有代谢合并症的老年高血压患者在接受/不接受他汀类药物治疗时的维生素D状态,以及与体重指数(BMI)和血脂参数的关系。材料和方法:研究组纳入2019年至2021年期间在穆列乌斯特心血管康复临床医院住院的89例高血压患者(61例接受他汀治疗)。ELISA法测定维生素D水平,光度法测定血脂参数。计算值为ldl -胆固醇和BMI。结果:51%的受试者存在与高血压相关的肥胖和糖尿病。89%的高血压患者存在维生素D缺乏症。研究对象血清维生素D平均值为14.27±11.96 ng/mL。在维生素D水平上,性别、是否使用他汀类药物以及糖尿病是否合并症没有显著差异。血清HDL-胆固醇与甘油三酯浓度呈负相关(r = -0.3988, p = 0.0008), HDL水平与BMI呈负相关(r = -0.3114, p = 0.0475)。结论:无论是否接受他汀类药物治疗,大多数高血压患者的维生素D水平都不理想,这揭示了伴随评估维生素D水平的重要性,特别是在有慢性代谢合并症的老年受试者中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of Vitamin D Levels in Relation to Statin Therapy in Elderly Hypertensive Patients with Comorbidities
Abstract Background: Statin therapy is commonly used on the long term in hypertensive patients with dyslipidemia and can interfere with vitamin D metabolism. Overweight/obesity and type 2 diabetes mellitus (DM) are frequently associated with hypertension. The aim of the study was the assessment of vitamin D status in elderly hypertensive patients with metabolic comorbidities with/without statin therapy, in relation to body mass index (BMI) and lipid profile parameters. Material and methods: The study group included 89 hypertensive patients (61 statin-treated) admitted to the Cardiovascular Rehabilitation Clinical Hospital in Târgu Mureș between 2019 and 2021. Vitamin D levels were measured by ELISA method, lipid profile parameters by photometric procedures. Calculated values were LDL-cholesterol and BMI. Results: Obesity and DM were present in association with hypertension in 51% of the subjects. A total of 89% of the enrolled hypertensive patients had hypovitaminosis D. Average serum vitamin D of the studied subjects was 14.27 ± 11.96 ng/mL. No significant difference was obtained in vitamin D levels depending on gender, the presence/absence of statin therapy, and DM as a comorbidity. A negative correlation was seen between serum HDL-cholesterol and triglyceride concentrations (r = –0.3988, p = 0.0008) and between HDL levels and BMI (r = –0.3114, p = 0.0475). Conclusions: Suboptimal vitamin D levels were present in the majority of the studied hypertensive patients regardless of the statin therapy, which reveals the importance of concomitant assessment of vitamin D levels, especially in elderly subjects presenting chronic metabolic comorbidities.
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