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引用次数: 0
摘要
消化道肿瘤是严重威胁人类健康的疾病。有效识别具有特异性特征的消化道肿瘤标志物是消化道肿瘤疾病诊断、治疗、识别和康复分析的关键。以Oncomine、Gene Expression Profiling Interactive Analysis (GEPIA)、Human Protein Atlas (HPA)数据库为代表的公共医疗数据资源平台,为医学领域的知识管理和知识发现提供了新的途径。因此,我们建立了肿瘤标志物识别的计算分析框架,从海量、多样化的数据集中挖掘,探讨非smc凝血素I复合物亚单位G (Non-SMC Condensin I Complex, Subunit G, NCAPG)在胃肠道肿瘤中的诊断、表达和预后。患者生存和相关分析表明,NCAPG mRNA和蛋白水平在不同消化道肿瘤中高表达。本研究为胃肠道肿瘤患者提供了新的治疗方法,也为公众提供了参考。
Bioinformatics and Patient Survival Analysis of Digestive Tract Tumor Marker NCAPG Based on Public Medical Databases
The digestive tract tumor disease is a serious threat to human health. The effective identification of digestive tract tumor markers with specific characteristics is the key to the diagnosis, treatment, recognition, and rehabilitation analysis of digestive tract tumor diseases. Public medical data resource platforms represented by Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), and Human Protein Atlas (HPA) databases provide a new path for knowledge management and knowledge discovery in the medical field. Therefore, a computational analysis framework for tumor marker recognition was established to mine from massive and diversified data sets and explore the diagnosis, expression, and prognosis of Non-SMC Condensin I Complex, Subunit G (NCAPG) in gastrointestinal tumors. Patient survival and correlation analyses suggested the mRNA and protein levels of NCAPG were highly expressed in different digestive tract tumors. This study provides new treatment methods for patients with gastrointestinal cancer and a reference for the public.