Comparative outcomes of MACE after Drug eluting balloon Vs. Drug Eluting Stent in treatment of in-stent restenosis (ISR) patients presented with acute coronary syndrome.

Background: Currently, patients with coronary artery disease are advised to use coronary stenting as their primary revascularization method. This study aims to compare outcome of MACE after DEB Vs DES in treatment of patients within stent restenosis (ISR) presented with chest pain. Methodology: The current study was Quasi experimental study carried out at the Department of Cardiology, MTI-HMC Peshawar for duration of six months from 21 April 2021 to 21 Nov 2021. In this study, 94 patients in DEB group and 94 patients in DES group were followed for 06 months to look for development of MACE.  All data was collected through a well-defined proforma. Data was entered on computer software SPSS version 22. Results: In DEB group, 52 (55.3%) male patients and 42 (44.7%) female patients were recorded whereas in DES group, 57 (60.6%) male patients while 37 (39.4%) female patients were recorded. In DEB group, 15 (16.0%) patients were recorded with MACE whereas in DES group, 38 (40.4%) patients were recorded with MACE. Conclusion: Our study showed that DEB is superior to DES in the management of in-stent restenosis and results in fewer major adverse cardiovascular events (MACE), so DEB may be considered as a treatment option for CAD patients admitted to our setting in in order to reduce mortality and morbidity associated to restenosis in such patients.