CHARACTERISTIC CHANGES IN SOME CLINICAL LABORATORY PARAMETERS OF THE SARS-COV-2 INFECTION IN THE COURSE OF THE DISEASE

Global coronavirus disease 2019 (COVID-19) has posed major challenges to clinical laboratories, from initial diagnosis to patient monitoring and treatment. Some routine laboratory markers reveal a range of changes in patients with COVID-19. Among the most frequently observed are: increased levels of C-Reactive Protein (CRP), Lactate dehydrogenase (LDH), D-Dimer neutrophilia with lymphopenia and decreased platelet count. The aim of our study is to present the changes in the values of CRP, LDH, D-Dimer, number of Thrombocytes (PLT), Lymphocytes (Ly) and Neutrophils (Neu) during hospitalization and at the discharge of patients with Sars-Cov-2. Materials and methods: The object of the study are clinical laboratory results of 106 patients who underwent hospital treatment for Covid -19 in the "St. Ivan Rilski" St. Zagora, divided into two groups. The first group (Group I) is in the period November-December 2020, the second group (Group II) patients were hospitalized in April 2021. The values of CRP, LDH, D-Dimer, number of platelets, Ly, Neu from the day of the patient's admission to the hospital and from his discharge were examined. Results and discussion: In 100% of the examined patients in the first group CRP with values at the time of admission to the hospital (TAH) 88.70 ± 63.132 mg/L. LDH was increased in three of the groups in more than 90% of the patients, with the highest values of the enzyme being recorded in Group II at the end of hospitalization, 802.33 U/L (± 557.836). In the studied groups, we found significantly more patients with elevated values in both groups at discharge (Group I 49.12% and Group II 46.94%). The highest number of patients with thrombocytopenia was observed in Group II at the time of admission to the hospital, 26.53% (n=13). Conclusion: Quantification of these and other laboratory parameters could significantly aid the detection of at-risk patients and reveal disease severity. They represent objective and standardized criteria guiding therapy.