雌激素及其受体在前列腺良性和恶性疾病中的作用:第一部分

Q4 Medicine
I. García-Figueredo , M.N. Candia , C.M. Pereda-Meira , C.M. Laborí-Carda
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引用次数: 0

摘要

许多关于前列腺癌分子基础的研究都集中在雄激素的作用上,但雌激素已被证明与前列腺癌的发生和发展有关。在本文中,我们回顾了实验室和临床证据,证明雌激素可能是前列腺增生和前列腺癌发生发展的原因。我们还研究了与雌激素作用相关的更重要的机制,包括:直接遗传毒性、高催乳素血症、炎症和受体介导的作用。此外,我们分析了已知的雌激素受体(α和β)在前列腺疾病中的功能。观察到的证据表明,雌激素受体α在正常前列腺和前列腺癌的发展中都起着至关重要的作用,而雌激素受体β在前列腺癌中与前列腺上皮组织的分化和许多抗增殖作用有关。然而,它们的一些同工异构体与癌症的发生和发展机制有关。最后,我们认为应该开展更多与雌激素作用相关的研究,以更好地了解雌激素在前列腺癌发展中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Papel de los estrógenos y sus receptores en las enfermedades benignas y malignas prostáticas: Parte 1

Numerous studies on the molecular basis of prostate cancer focus on the role of androgens, but estrogens have been shown to be linked to prostate cancer development and progression. In the present article, we reviewed the laboratory and clinical evidence, demonstrating that estrogens can be the cause of the development and progression of prostatic hyperplasia and prostate cancer. We also studied the more significant mechanisms related to estrogen action, which include: direct genotoxicity, hyperprolactinemia, inflammation, and receptor-mediated action. In addition, we analyzed the functions of the known estrogen receptors (alpha and beta) in diseases of the prostate. The evidence observed suggests that estrogen receptor alpha plays an essential role in the development of both the normal prostate and the cancer, whereas estrogen receptor beta is related to the differentiation of the prostatic epithelial tissue and numerous antiproliferative actions in prostate cancer. Nevertheless, some of their isoforms are associated with mechanisms of cancer initiation and progression. Finally, we believe that more studies related to estrogen action should be carried out to better understand the role estrogens play in the development of prostate cancer.

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来源期刊
Revista mexicana de urologia
Revista mexicana de urologia Medicine-Urology
CiteScore
0.20
自引率
0.00%
发文量
49
期刊介绍: Revista Mexicana de Urología (RMU) [Mexican Journal of Urology] (ISSN: 0185-4542 / ISSN electronic: 2007-4085) is bimonthly publication that disseminates research by academicians and professionals of the international medical community interested in urological subjects, in the format of original articles, clinical cases, review articles brief communications and letters to the editor. Owing to its nature, it is publication with international scope that disseminates contributions in Spanish and English that are rigorously reviewed by peers under the double blind modality. Neither journalistic documents nor those that lack rigorous medical or scientific support are suitable for publication.
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