内皮细胞对模型血管分叉处可控脉动血流的反应

Proceedings of 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Pub Date : 1994-11-03 DOI:10.1109/IEMBS.1994.412039

N. Okada, O. Sugita, T. Miida, Y. Makino, N. Komoro

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引用次数: 0

摘要

作者使用模型血管将猪主动脉内皮细胞暴露在不同的血流条件下。该模型由玻璃管制成，由主管和侧支组成，侧支的角度为90/spl°/。主管剪切速率为20秒/sup -1/，侧支剪切速率为29秒/sup -1/。乳酸脱氢酶(LDP)作为细胞损伤的指标。在培养皿中添加天然脂蛋白、氧化亚油酸和非氧化亚油酸，比较细胞乳酸脱氢酶的变化。侧支细胞LDH低于主管细胞LDH。

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Endothelial cell responses to controlled pulsatile flow at the bifurcation of a model vessel

The authors exposed endothelial cells of the porcine aorta to different flow conditions using a model vessel. This model is made of glass tube and consists of a main tube and a side branch of which angle is 90/spl deg/. The shear rate of the main tube was 20 sec/sup -1/, while that of the side branch was 29 sec/sup -1/. Lactic dehydrogenase (LDP) was measured as an indicator of cell damage. Changes of LDH from cultured cells in dishes by adding native lipoprotein, oxidized and non-oxidized linoleic acid were also examined for comparisons. LDH was lower in the cells of the side branch than in those of the main tube.<>

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Proceedings of 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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