Biologically inspired circuit model for simulation of acetylcholine gated ion channels of the postsynaptic membrane at synaptic cleft

The variable conductance of postsynaptic membrane of neuron dependence on the acetylcholine-receptor binding activity is represented by enzyme modified field effect transistor (ENFET) sensitive to acetylcholine. Acetylcholine sensitive ENFET functions not only as a voltage controlled conductance but can also provide a means of measurement of specific neurotransmitters that bind with the receptor sites of postsynaptic membrane. This analog is incorporated into the famous Hodgkin-Huxley (H-H) model of neuron to substitute the variable Na+ conductance. Simulation is performed in MATLAB environment both for normal (excitatory) and pathologic states and results are presented.