由于其广谱抗菌活性,次氯酸已成为传统抗生素的潜在替代品

Akl Maher M
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摘要

次氯酸(HOCl)是一种有效的抗菌剂,近年来作为传统抗生素的潜在替代品而受到关注。HOCl是由人体免疫系统对感染的反应产生的,以其广谱抗菌活性而闻名。它对多种微生物有效,包括细菌、病毒和真菌,并且已被证明比许多传统抗生素更有效。HOCl的主要优点之一是它能够杀死细菌而不促进抗生素耐药性的发展。与针对特定细菌结构或过程的传统抗生素不同,HOCl通过破坏多种细胞成分起作用,使细菌更难以产生耐药性。HOCl的另一个优点是它的安全性。与许多传统抗生素不同,HOCl对人体细胞没有毒性,也不会引起胃肠道不适或过敏反应等副作用。总的来说,HOCl作为传统抗生素的潜在替代品显示出巨大的希望,特别是在面对抗生素耐药性上升的情况下。随着进一步的研究,它可能成为对抗传染病的重要工具。本文就HOCl的抗菌作用机制、临床应用前景及未来研究方向进行了探讨。本文综述了次氯酸(HOCl)作为抗生素的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hypochlorous acid has emerged as a potential alternative to conventional antibiotics due to its broad-spectrum antimicrobial activity
Hypochlorous acid (HOCl) is a potent antimicrobial agent that has recently gained attention as a potential alternative to conventional antibiotics. HOCl is produced by the human immune system in response to infection and is known for its broad-spectrum antimicrobial activity. It is effective against a wide range of microorganisms, including bacteria, viruses, and fungi, and has been shown to be more effective than many conventional antibiotics. One of the key advantages of HOCl is its ability to kill bacteria without promoting the development of antibiotic resistance. Unlike conventional antibiotics, which target specific bacterial structures or processes, HOCl acts by disrupting multiple cellular components, making it much more difficult for bacteria to develop resistance. Another advantage of HOCl is its safety profile. Unlike many conventional antibiotics, HOCl is not toxic to human cells and does not cause side effects such as gastrointestinal upset or allergic reactions. Overall, HOCl shows great promise as a potential alternative to conventional antibiotics, particularly in the face of rising antibiotic resistance. With further research, it may become an important tool in the fight against infectious diseases. Herein, we discuss the mechanisms of HOCl antimicrobial action, its potential clinical applications, and future directions for research. This review aims to provide an overview of the use of hypochlorous acid (HOCl) as an antibiotic agent.
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