[串联质谱法快速检测血清中巴比妥类药物的筛选方法]。

Beitrage zur gerichtlichen Medizin Pub Date : 1992-01-01

P Bold, H Brzezinka, H Budzikiewicz

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引用次数: 0

摘要

提出了一种检测血清中巴比妥类药物的质谱筛选方法。巴比妥酸盐在EI条件下的碎裂导致HNCO的损失。因此，43 u的“中性损失扫描”允许指示这类化合物可能存在的代表。鉴定可以通过“子离子”或“母离子扫描”来实现。因此，在血清中可以检测到10微克/毫升的阿普罗、戊托和苯巴比妥。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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[A screening method for rapid detection of barbiturates in serum using tandem mass spectrometry].

A mass spectrometric screening method for the detection of barbiturates in serum will be presented. Fragmentation of barbiturates under EI conditions leads to a loss of HNCO. Therefore, "neutral loss scans" of 43 u allow the indication of possibly existing representatives of this class of compounds. Identification can be achieved by "daughter" or "parent ion scans". Thus, 10 micrograms/ml apro-, pento- and phenobarbital could be detected in serum.

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Beitrage zur gerichtlichen Medizin

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