来自计算模型的见解:利用电刺激表征侏儒和阳伞视网膜神经节细胞

2021 14th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics (CISP-BMEI) Pub Date : 2021-10-23 DOI:10.1109/CISP-BMEI53629.2021.9624239

Xiaoyu Song, Donglin Wu, Shirong Qiu, Zhengyang Liu, Feng Zhou, Saidong Ma, Liming Li, Tianruo Guo

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引用次数: 1

摘要

视网膜假体寻求通过刺激视网膜退行性疾病患者存活的视网膜内神经元来创造人工视觉。然而，迄今为止，所有植入物的测试性能仍然处于初级阶段，无法克服法律盲目性的门槛。更好地了解人工电刺激下的视网膜生理将显著提高刺激性能，从而创造出与自然视觉非常相似的有意义的视网膜输出模式。本计算机研究表征了两种视网膜神经节细胞(RGC)亚型:灵长类视网膜中的侏儒细胞和伞细胞的电反应。RGC之间的阈值差异可能受到RGC位置和多种RGC形态特征的影响。本研究成果可为下一代视觉假体刺激方法的设计提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Insights from computational modelling: Characterising Midget and Parasol Retinal Ganglion Cells using Electrical Stimulation

Retinal prostheses seek to create artificial vision by stimulating surviving inner retinal neurons of patients with retinal degenerative diseases. However, the performance of all implants tested to date have remained rudimentary incapable of overcoming the threshold for legal blindness. Better understanding of retinal physiology under artificial electrical stimulation will be significantly improve the stimulation performance to create meaningful patterns of retinal outputs, that closely resemble those in natural vision. This in silico study characterize the electric response of two retinal ganglion cell (RGC) subtypes: midget and parasol cells in primate retina. The threshold difference between RGCs can be by influenced by RGC locations and multiple RGC morphological properties. The knowledge gained from this study could provide insights towards the design of the stimulation methods for next-generation visual prosthesis.

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来源期刊

2021 14th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics (CISP-BMEI)

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