[安慰剂和佐匹克隆对睡眠纺锤波的周期性放电]。

I Spieweg, S Sanders, S Kubicki
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引用次数: 0

摘要

根据我们的经验(顶叶),睡眠纺锤波经常周期性地出现。连续的睡眠纺锤波的间隔约为4秒。95%的睡眠纺锤波持续时间不超过40 s,因此出现的连续周期性睡眠纺锤波不超过10个。在本研究中,10名年龄在57至77岁之间的受试者给予安慰剂和7.5 mg佐匹克隆。在verum的作用下,我们发现睡眠纺锤波系列加倍。然而,周期主轴之间的距离和主轴系列的长度保持不变。不同受试者产生睡眠纺锤波序列的能力差异很大。例如,一个受试者在安慰剂夜只产生一个睡眠纺锤波系列(在verum下有三个),另一个受试者产生95个(在verum下有130个)。本研究的结果与先前的一项比较安慰剂、戊巴比妥、甲氧奎酮、卡布罗莫、氟硝西泮、三唑仑和洛美西泮的研究结果相吻合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Periodic discharges of sleep spindles with placebo and zopiclone].

According to our experiences (parietal) sleep spindles often show a periodical appearance. Successive sleep spindles in series have a distance of about four seconds. In 95% the duration of such series of sleep spindles is not longer than 40 s, so that there appears no more than ten successive periodical sleep spindles. In the present study ten subjects aged between 57 and 77 years were given Placebo and 7.5 mg Zopiclone. Under the effect of verum we found a doubling of sleep spindle series. However, the distance between the periodical spindles and the length of the spindle series remained unchanged. The variance in the ability to generate sleep spindle series was very high across subjects. One subject for example produced only one sleep spindle series in the Placebo-night (three under verum) and another subject on the other hand 95 (under verum 130). The results of the present study well corresponding to the results of a former investigation comparing Placebo, Pentobarbital, Methaqualon, Carbromal, Flunitrazepam, Triazolam and Lormetazepam.

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