{"title":"细胞生物学家的观点:PROTAC-HDAC降解物的发展前沿。","authors":"A. Sobko","doi":"10.31219/osf.io/vua9r","DOIUrl":null,"url":null,"abstract":"Structure of the article: HDACsClassificationEpigenetic regulatorsHDACs and Epigenetics of AgingNon-histone substrates of HDACsHistone modifying multiprotein complexesInsight from knockout studiesHDAC inhibitorsMolecular and cellular mechanisms of action of HDAC inhibitorsMolecular mechanism of actionCellular mechanism of actionPre-clinical and clinical use of HDAC inhibitors PROTACs and Molecular Glues: bi-valent and mono-valent degradersClass I HDAC degradersHDAC6 degradersPROTACs targeting NAD+-dependent histone deacetylasesNon-selective HDAC degradersHistone methyltransferase-specific PROTACsHDAC PROTACs: molecular mechanismsHDAC PROTACs: cellular mechanismsDesign and Development of PROTAC-mediated HDAC DegradationTesting HDAC degradersOpen key questions and perspectives in developing HDAC-degradersLiterature CitedAcknowledgments","PeriodicalId":172569,"journal":{"name":"Journal of Stem Cell Research & Therapeutics","volume":"18 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cell biologist’s perspective: Frontiers in Development of PROTAC-HDAC degraders.\",\"authors\":\"A. Sobko\",\"doi\":\"10.31219/osf.io/vua9r\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Structure of the article: HDACsClassificationEpigenetic regulatorsHDACs and Epigenetics of AgingNon-histone substrates of HDACsHistone modifying multiprotein complexesInsight from knockout studiesHDAC inhibitorsMolecular and cellular mechanisms of action of HDAC inhibitorsMolecular mechanism of actionCellular mechanism of actionPre-clinical and clinical use of HDAC inhibitors PROTACs and Molecular Glues: bi-valent and mono-valent degradersClass I HDAC degradersHDAC6 degradersPROTACs targeting NAD+-dependent histone deacetylasesNon-selective HDAC degradersHistone methyltransferase-specific PROTACsHDAC PROTACs: molecular mechanismsHDAC PROTACs: cellular mechanismsDesign and Development of PROTAC-mediated HDAC DegradationTesting HDAC degradersOpen key questions and perspectives in developing HDAC-degradersLiterature CitedAcknowledgments\",\"PeriodicalId\":172569,\"journal\":{\"name\":\"Journal of Stem Cell Research & Therapeutics\",\"volume\":\"18 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-08-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Stem Cell Research & Therapeutics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31219/osf.io/vua9r\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Stem Cell Research & Therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31219/osf.io/vua9r","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Cell biologist’s perspective: Frontiers in Development of PROTAC-HDAC degraders.
Structure of the article: HDACsClassificationEpigenetic regulatorsHDACs and Epigenetics of AgingNon-histone substrates of HDACsHistone modifying multiprotein complexesInsight from knockout studiesHDAC inhibitorsMolecular and cellular mechanisms of action of HDAC inhibitorsMolecular mechanism of actionCellular mechanism of actionPre-clinical and clinical use of HDAC inhibitors PROTACs and Molecular Glues: bi-valent and mono-valent degradersClass I HDAC degradersHDAC6 degradersPROTACs targeting NAD+-dependent histone deacetylasesNon-selective HDAC degradersHistone methyltransferase-specific PROTACsHDAC PROTACs: molecular mechanismsHDAC PROTACs: cellular mechanismsDesign and Development of PROTAC-mediated HDAC DegradationTesting HDAC degradersOpen key questions and perspectives in developing HDAC-degradersLiterature CitedAcknowledgments
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