断奶后大鼠血管平滑肌反应的个体发生。

E E Soltis, P S Newman
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引用次数: 0

摘要

本研究研究了3、7和11周龄雄性sd大鼠主动脉和尾动脉制剂中收缩和舒张反应的个体发生。与7周龄和11周龄的大鼠相比,3周龄大鼠血管平滑肌对去甲肾上腺素、血清素、氯化钾、电刺激和无钾生理溶液的收缩反应显著增加。内皮依赖性乙酰胆碱诱导的松弛和β -肾上腺素受体介导的异丙肾上腺素诱导的松弛随着成熟而显著减弱。这些数据表明,在大鼠断奶后的成熟期,主动脉和尾动脉平滑肌反应性发生了显著变化。这些改变可能对心血管和体温调节功能以及动物的年龄有重大影响,当用作确定各种疾病状态(如高血压)涉及的致病机制的实验模型时。因此,需要进一步的研究来确定是否在阻力血管水平上发生类似的血管功能变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ontogeny of vascular smooth muscle responsiveness in the postweaning rat.

This study investigated the ontogeny of contractile and relaxation responses in aortic and tail artery preparations from 3-, 7-, and 11-week-old male Sprague-Dawley rats. Contractile responses to norepinephrine, serotonin, KCl, electrical stimulation, and potassium-free physiological solution were significantly increased in vascular smooth muscle from 3-week-old rats when compared to 7- and 11-week-old rats. Endothelium-dependent acetylcholine-induced relaxation and beta-adrenoceptor mediated isoproterenol-induced relaxation were significantly attenuated with maturation. These data demonstrate that significant changes occur in aortic and tail artery smooth muscle responsiveness during the postweaning maturational period of the rat. The alterations may have significant implications with regard to cardiovascular and thermoregulatory function as well as the age of the animal when utilized as an experimental model for identifying pathogenic mechanisms involved in various disease states such as hypertension. As such, further studies are warranted to determine if similar ontogenic changes in vascular function occur at the level of the resistance vessel.

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