小檗提取物对金黄色葡萄球菌、大肠杆菌和奇异变形杆菌的抑菌活性研究

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引用次数: 0

摘要

草药和药用植物被广泛用作最早的药物。近年来,随着细菌对现有抗生素耐药性的不断发展,新型抗菌药物的开发越来越受到人们的关注。合欢花是一种落叶乔木,有复叶,扁平的椭圆形果实和圆形的奶油色种子。它生长在野外,在南亚和非洲的许多地方也有种植。有大量的数据支持合欢的愈合和治疗特性。小檗在不同的传统中被用于治疗各种疼痛和炎症。本实验用小黄花提取物对金黄色葡萄球菌、大肠杆菌和变形杆菌三种不同的菌株进行了抑菌作用。用甲醇和乙醇提取物检测其抑菌活性。结果表明,与庆大霉素相比,大菱鲆对被试物种有明显的生长抑制作用。结果证实了该植物的传统用途,表明其具有开发抗菌药物的潜力。需要进一步的工作来分离、结构阐明和表征负责这种活性的生物活性成分。这些分离的天然产物应该在体内和体外进行抗菌活性筛选,并可能开发为市场上昂贵的合成抗菌剂的廉价替代品。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antibacterial Activity of Extracts of Albizia lebbeck Against Staphylococcus aureus, Escherichia coli and Proteus mirabilis
Herbs and medicinal plants have widely been used as the first medicines. The development of new antibacterial drugs got more attention recently because of the continuous development of resistance of bacteria to the current antibiotics. Albizia lebbeck is a type of deciduous tree that has compound leaves, flat oblong fruit and round cream-colored seeds. It grows in wild and is also planted in many parts of South Asia and Africa. There is a significant amount of data to support the healing and curing properties of Albizia lebbeck. A lebbeck has been used in the treatment of various pain and inflammatory conditions in various traditions. Here we used the extracts of Albizia lebbeck against three different bacterial strains namely Staphylococcus aureus, Escherichia coli and Proteus Mirabilis. Methanol and Ethanol extracts were used to check their antibacterial activity. Results indicated that Albizia lebbeck showed growth inhibition pattern against the tested species, when compared with gentamicin. The results authenticated its traditional use and indicated promising potential of this plant to be developed as antibacterial agent. Further work is needed for isolation, structure elucidation and characterization of bioactive constituents responsible for this activity. These isolated natural products should be screened in vivo and in vitro for antibacterial activity and may be developed as cheap alternatives to costly synthetic antimicrobial agents available in market.
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