阴茎癌患者的前瞻性临床病理研究:单一机构经验

Sushil Kumar, A. Gupta, B. Pandey
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摘要

背景:阴茎癌在西方国家是一种不常见的恶性肿瘤,但在亚洲、非洲和南美洲的许多国家,它构成了一个主要的健康问题,在这些国家,它可能占所有恶性肿瘤的10%。材料与方法:对2013 - 2015年连续42例阴茎癌患者进行治疗。记录临床和病理情况并进行前瞻性研究。结果:20/42(48%)患者年龄在60岁及以上。社会经济状况较差的患者占多数,32/42(76.1%)。42例患者中有28例(66.6%)以阴茎头为最常见的表现部位。21例(50%)患者最常见的症状是阴茎溃疡脓流。31/42例患者为长期吸烟者或嚼烟者。24/42例(57%)可见腹股沟淋巴结。腹股沟淋巴结清扫最常见的并发症是淋巴水肿,19例(45.2%)。42例患者中有12例在最终的组织病理学检查中发现腹股沟淋巴结转移。50%的患者为II级原发肿瘤。结论:阴茎癌发病率在60岁左右达到高峰。文盲、低社会经济地位和包茎是阴茎癌的主要易感因素。淋巴结转移与T3和高级别病变(II级和III级)等因素相关。与腹股沟淋巴结清扫相关的并发症发生率高,最常见的是淋巴水肿。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prospective Clinicopathological Study of Penile Cancer Patients : A Single Institution Experience
Background: Carcinoma of the penis is an uncommon malignancy in Western countries but constitutes amajor health problem in many countries in Asia, Africa, and South America, where it may comprise up to10% of all malignancies.Materials and Method: 42 consecutive patients of carcinoma penis were treated from 2013 to 2015. Clinicaland pathological profies were recorded and studied prospectively.Results: 20/42 (48%) patients were of the age group 60 and above. majority of patients belonged to poorsocioeconomic status, 32/42 patients(76.1%). Glans of the penis was the most common site of presentationin 28/42patients(66.6%). The most common symptoms were pus discharge from the penile ulcer in 21patients(50%). 31/42 patients were chronic smoker or tobacco chewer. Inguinal lymph nodes were palpablein 24/42 (57%). The most common complication associated with Groin node dissection was lymphedema in19 patients (45.2%). 12/42 patients had inguinal lymph node metastasis in final histopathological examinationreport. 50 % patients had grade II primary tumor.Conclusion: Incidence of carcinoma penis peaks in the 6thdecade of life. Illiteracy, low socio-economicstatus and phimosis appear to be main predisposing factors for carcinoma of penis. Nodal metastasis wassignificantly associated with factors like T3 and high grade lesions (grade II & III). Complication rate relatedto groin node dissection is high, commonest being lymphedema.
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