{"title":"我们能给心力衰竭患者乙酰唑胺吗?系统回顾","authors":"Maria Eduarda Santos Luna","doi":"10.56294/dm202212","DOIUrl":null,"url":null,"abstract":"Introduction: Heart failure (HF) is a clinical syndrome characterized by a variety of symptoms and signs due to structural and/or functional abnormalities of the heart leading to decreased heart rate, cardiac output and/or increased intracardiac pressures. Studies suggest that acetazolamide could improve the efficacy of ASA diuretics, which could lead to improved natriuresis and diuresis.\nAims: To evaluate the effectiveness of acetazolamide in improving congestion symptoms in patients with Heart Failure.\nMethods: A systematic review will be carried out, following the PRISMA methodology, which will include a search in Pubmed, Scopus, Web of Science databases without time restriction.\nResults: 5 studies were included, of which 4 were clinical trials.\nConclusions: After comprehensive and detailed analysis of the included studies, we found limited evidence suggesting that the use of acetazolamide may be effective in the treatment of heart failure, especially as additional or complementary therapy to other treatments. However, it is important to keep in mind that the results of the pilot studies are limited and that more research is required to fully evaluate the efficacy and safety of acetazolamide in the treatment of heart failure. The use of acetazolamide in patients with heart failure may be controversial and requires careful evaluation of clinical risks and benefits before it is considered as a treatment.","PeriodicalId":388306,"journal":{"name":"Data & Metadata","volume":"27 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Can we administer Acetazolamide in patients with heart failure? A systematic review\",\"authors\":\"Maria Eduarda Santos Luna\",\"doi\":\"10.56294/dm202212\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Heart failure (HF) is a clinical syndrome characterized by a variety of symptoms and signs due to structural and/or functional abnormalities of the heart leading to decreased heart rate, cardiac output and/or increased intracardiac pressures. Studies suggest that acetazolamide could improve the efficacy of ASA diuretics, which could lead to improved natriuresis and diuresis.\\nAims: To evaluate the effectiveness of acetazolamide in improving congestion symptoms in patients with Heart Failure.\\nMethods: A systematic review will be carried out, following the PRISMA methodology, which will include a search in Pubmed, Scopus, Web of Science databases without time restriction.\\nResults: 5 studies were included, of which 4 were clinical trials.\\nConclusions: After comprehensive and detailed analysis of the included studies, we found limited evidence suggesting that the use of acetazolamide may be effective in the treatment of heart failure, especially as additional or complementary therapy to other treatments. However, it is important to keep in mind that the results of the pilot studies are limited and that more research is required to fully evaluate the efficacy and safety of acetazolamide in the treatment of heart failure. The use of acetazolamide in patients with heart failure may be controversial and requires careful evaluation of clinical risks and benefits before it is considered as a treatment.\",\"PeriodicalId\":388306,\"journal\":{\"name\":\"Data & Metadata\",\"volume\":\"27 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-12-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Data & Metadata\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.56294/dm202212\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Data & Metadata","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.56294/dm202212","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
摘要
心衰(Heart failure, HF)是一种临床综合征,以心脏结构和/或功能异常导致心率、心输出量降低和/或心内压升高为特征,表现为多种症状和体征。研究表明,乙酰唑胺可以提高ASA利尿剂的疗效,从而改善尿钠和利尿。目的:评价乙酰唑胺对心力衰竭患者充血症状的改善效果。方法:采用PRISMA方法进行系统综述,检索Pubmed、Scopus、Web of Science数据库,不受时间限制。结果:共纳入5项研究,其中4项为临床试验。结论:在对纳入的研究进行全面和详细的分析后,我们发现有限的证据表明使用乙酰唑胺可能有效治疗心力衰竭,特别是作为其他治疗的补充或补充治疗。然而,重要的是要记住,初步研究的结果是有限的,需要更多的研究来充分评估乙酰唑胺治疗心力衰竭的有效性和安全性。在心力衰竭患者中使用乙酰唑胺可能存在争议,在考虑将其作为一种治疗方法之前,需要仔细评估临床风险和益处。
Can we administer Acetazolamide in patients with heart failure? A systematic review
Introduction: Heart failure (HF) is a clinical syndrome characterized by a variety of symptoms and signs due to structural and/or functional abnormalities of the heart leading to decreased heart rate, cardiac output and/or increased intracardiac pressures. Studies suggest that acetazolamide could improve the efficacy of ASA diuretics, which could lead to improved natriuresis and diuresis.
Aims: To evaluate the effectiveness of acetazolamide in improving congestion symptoms in patients with Heart Failure.
Methods: A systematic review will be carried out, following the PRISMA methodology, which will include a search in Pubmed, Scopus, Web of Science databases without time restriction.
Results: 5 studies were included, of which 4 were clinical trials.
Conclusions: After comprehensive and detailed analysis of the included studies, we found limited evidence suggesting that the use of acetazolamide may be effective in the treatment of heart failure, especially as additional or complementary therapy to other treatments. However, it is important to keep in mind that the results of the pilot studies are limited and that more research is required to fully evaluate the efficacy and safety of acetazolamide in the treatment of heart failure. The use of acetazolamide in patients with heart failure may be controversial and requires careful evaluation of clinical risks and benefits before it is considered as a treatment.