遗传密码不是任意的

Nicolay Nicolaevich Kozlov
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摘要

该研究是在对实验数据进行数学分析的基础上进行的:一组基因和一组自然遗传密码。对DNA结构允许的5例基因重叠进行了研究。遗传密码的整体特征被引入考虑,这证明了基因对重叠的能力。有可能建立线粒体遗传密码中所有重新解释的密码子参与的功能(人类和其他生物),以及这些代码与标准代码的整体特征之间的显着差异。我们的结果使我们得出这样的结论:代码偏离标准会带来相当明显的功能负载。从上面的结果可以看出,对于所有密码子的语义家族,两个蛋白质序列可以被写入几乎不被相同的DNA区域阻塞,为此,您可以使用最有利的(根据重叠中氨基酸的组合)这样一个紧凑的基因符号的5个变体之一(5个重叠情况)。不超过5%的氨基酸对存在分类禁令,包括标准代码和所有14个已知的非标准代码。这些东西。所有15个代码表都具有相同的公共属性。这样就不会有任何随意性和偶然性。选择遗传密码的结构。在这些研究过程中,形成了遗传密码的数学理论,已经发表了第一阶段的研究成果(见附录),编写了一本关于第二阶段成果的书,准备出版,并在第三阶段开展了工作。基础研究的这一研究课题似乎是取之不尽的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The genetic code is not arbitrary
The study was carried out on the basis of mathematical analysis of experimental data: sets of genes and sets of natural genetic codes. All 5 cases of gene overlaps allowed by the DNA structure were investigated. Integral characteristics of genetic codes are introduced into consideration, which testify to the ability to overlap pairs of genes. It was possible to establish the functions in which all reinterpreted codons in the mitochondrial genetic codes (of humans and other organisms) participate, as well as a significant difference between the integral characteristics of such codes from the standard code. Our results allow us to conclude that code deviations from the standard carry a quite clear functional load. It follows from the above results that for all semantic families of codons, two protein sequences can be written that are practically not obstructed by the same DNA region, and for this you can use the most favorable (according to the combination of amino acids in the overlap) one of the 5 variants of such a compact notation of genes (5 cases overlap). A categorical ban exists for no more than 5% of amino acid pairs, both for the standard code and for all 14 known non-standard codes. Those. All 15 code tables have the same common property. This leaves no chance for any arbitrariness, chance. choose the structure of the genetic code. In the course of these studies, a mathematical theory of the genetic code has been developed, the first stage of research has already been published (see Appendix), a book of the results of the second stage has been prepared for publication, and work has been carried out on the third stage. It seems that this research topic of fundamental research is inexhaustible.
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