我们新设计的补充剂对降低胰腺癌高风险的有效性

H. Ikeda, T. Ikeda, H. Tahara
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引用次数: 0

摘要

通过分析外周血中的微RNA (miRNA),早期发现胰腺癌成为可能。我们报告了我们新的预防干预方法,通过使用我们的原始补充剂来降低胰腺癌的风险,用于高风险的胰腺癌患者。目的:探讨血液中miRNA测定胰腺癌风险的方法,并探讨新研制的补充剂是否能有效降低胰腺癌的高风险。材料和方法:从14名未患病的成年人的血液中提取miRNA。他们包括7男7女,年龄在64 - 78岁之间,平均年龄67.6岁。使用下一代测序仪进行综合分析,并以表达评分(ES)计算胰腺癌的风险。服用了三个月的补充剂(β -葡聚糖和甲基白藜芦醇)后,通过分析血液样本中的miRNA反复进行风险测定。通过ES评估我们的肿瘤风险降低补充剂治疗的荷瘤风险变化。结果:14例患者中,有11例(79%)通过含瘤减量补充剂的主动干预方法,显著降低了表达评分(Wilcoxon检验;P <0.0052)。结论:对于那些有胰腺癌高风险的人,我们发现通过我们新设计的补充剂可以完美地降低ES。这是先发制人的有效做法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Usefulness of Our Newly Designed Supplements for Reducing the High Risk of Pancreatic Cancer
Early detection of pancreatic cancer became possible by analyzing micro RNA (miRNA) from peripheral blood. We report our new preventive intervention method to reduce the risk of pancreatic cancer by using our original supplements for patients with high risk of pancreas-bearing cancer. Purpose: The risk determination of pancreatic cancer by using miRNA from blood was examined, and it was investigated whether it was effective to decrease the high risk of pancreatic cancer by using supplements that we newly devised. Materials and Methods: For 14 adults who are not sick, the miRNA was extracted from the blood. They consisted of 7 men and 7 females, aged between 64 and 78 years old, averaging 67.6 years old. The encompassing analysis was performed using the next generation sequencer, and the risk of pancreatic cancer was calculated as Expression Score (ES). After three months of our supplements (beta-glucan and Methyl-resveratrol) were subjected to take, the risk determination was carried out repeatedly by analyzing miRNA from blood samples. Changes in tumor-bearing risk treated by our tumor risk-reduction supplements were evaluated by ES. Results: By the proactive intervention method of the tumor-bearing reduction supplements, the expression scores, in 11 cases (79%) in 14 cases, were reduced significantly (Wilcoxon test; p<0.0052) after taking supplements. Conclusion for those who have a high risk of pancreatic cancer, we found it possible to reduce ES perfectly by means of our newly designed supplements. This shows an effective practice of preemptive medicine.
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